PMID: 109534Jul 1, 1979

Regulation of autoimmune response to mouse thyroglobulin: influence of H-2D-end genes

The Journal of Immunology : Official Journal of the American Association of Immunologists
Y KongN R Rose


Studies were initiated to define the H-2-linked genetic control of response to self-determinants of MTg. In addition to the Ir gene control of H-2K end, a modifying effect of D end was seen. The extent of regulation depended upon the derivation of the K-end Ir-Tg gene(s) as well as the D-end genes. When the Ir-Tg gene was from good responder H-2k and H-Ss strains, and the H-2D-end gene from the d allele, antibody levels were moderate to high but cellular infiltration was significantly reduced. These findings demonstrate genetic interaction between I-region and D-end gene products in the response to a self-antigen, MTg.

Related Concepts

Dose-Response Relationship, Immunologic
Ir Genes
H-2 Antigens
Mice, Inbred Strains
Recombination, Genetic

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