Regulation of autophagy by inhibitory CSPG interactions with receptor PTPσ and its impact on plasticity and regeneration after spinal cord injury.

Experimental Neurology
Amanda Phuong TranJerry Silver

Abstract

Chondroitin sulfate proteoglycans (CSPGs), extracellular matrix molecules that increase dramatically following a variety of CNS injuries or diseases, have long been known for their potent capacity to curtail cell migrations as well as axon regeneration and sprouting. The inhibition can be conferred through binding to their major cognate receptor, Protein Tyrosine Phosphatase Sigma (PTPσ). However, the precise mechanisms downstream of receptor binding that mediate growth inhibition have remained elusive. Recently, CSPGs/PTPσ interactions were found to regulate autophagic flux at the axon growth cone by dampening the autophagosome-lysosomal fusion step. Because of the intense interest in autophagic phenomena in the regulation of a wide variety of critical cellular functions, we summarize here what is currently known about dysregulation of autophagy following spinal cord injury, and highlight this critical new mechanism underlying axon regeneration failure. Furthermore, we review how CSPGs/PTPσ interactions influence plasticity through autophagic regulation and how PTPσ serves as a switch to execute either axon outgrowth or synaptogenesis. This has exciting implications for the role CSPGs play not only in axon regeneration failure...Continue Reading

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Citations

Jul 11, 2020·Scientific Reports·Philippa M WarrenJessica C F Kwok
Jul 28, 2020·Frontiers in Cellular Neuroscience·Armin SamiShuxin Li
Dec 15, 2020·Journal of Biochemistry·Yuanhao GongKazuma Sakamoto
Mar 5, 2021·Experimental Neurology·Sadayuki ItoKazuma Sakamoto
Mar 7, 2021·International Journal of Molecular Sciences·Veselina PetrovaRichard Eva
Apr 5, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Chao MaMei Liu
May 12, 2021·Neurobiology of Disease·Lan ChengAngelo C Lepore
Jun 3, 2021·Cell and Tissue Research·Amanda Phuong TranJerry Silver
Jun 3, 2021·International Journal of Molecular Sciences·Kazuma SakamotoKenji Kadomatsu
Jun 24, 2021·Journal of Molecular Neuroscience : MN·Shan WenXifan Mei
Jul 17, 2021·Journal of Biochemistry·Masaaki MachinoKazuma Sakamoto

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