Regulation of autophagy by TGF-β: emerging role in kidney fibrosis

Seminars in Nephrology
Yan Ding, Mary E Choi

Abstract

Autophagy is a highly conserved homoeostatic mechanism for cell survival under conditions of stress, and is widely implicated as an important pathway in many biological processes and diseases. In progressive kidney diseases, fibrosis represents the common pathway to end-stage kidney failure. Transforming growth factor-β1 (TGF-β1) is a pleiotropic cytokine that has been established as a central mediator of kidney fibrosis. A recently emerging body of evidence from studies in renal cells in culture and experimental animal models suggests that TGF-β1 regulates autophagy and that autophagy regulates many critical aspects of normal and disease conditions associated with kidney fibrosis, such as tubulointerstitial fibrosis, glomerulosclerosis, and diabetic nephropathy. Here, we review the recent advances exploring the process of autophagy, its regulation by TGF-β1, and the implication in the pathogenesis of progressive kidney fibrosis and injury responses. Understanding the cellular and molecular bases of this process is crucial for identifying potential new diagnostic and therapeutic targets of kidney fibrosis.

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Related Concepts

Programmed Cell Death, Type II
Nodular Glomerulosclerosis
Cirrhosis
Kidney
Renal Tubule Structure
Proteinuria
Signal Transduction
Transforming Growth Factor beta
Mesangial Cells, Kidney
Autophagy

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