Abstract
A large proportion of p-azophenylarsonate (ARS)-specific antibodies from A/J mice share a cross-reactive idiotype (CRIA) that comprises a family of closely related but nonidentical clonotypes. I determined that only 2.6 % (7 out of 267) A/J ARS-specific monoclonal antibodies generated in the splenic focus system possess the predominant CRIA. Because ARS-specific B cells are present at a frequency of 1/68,000 B cells, the frequency of the entire idiotype family is 1 per 2.8 X 10(6) splenic B cells. Thus, there is a striking discrepancy between the representation of this idiotype at the clonal precursor cell level and the serum antibody response. In addition, BALB/c mice have the potential to generate CRIA-positive precursor cells within their nonimmune repertoire. When A/J mice are immunized with ARS-protein conjugates, the serum antibody response and precursor cell population are both dominated by CRIA. The frequency of CRIA-positive B cells increases over 100-fold after immunization, whereas CRIA-negative precursor cells may initially decrease, followed by a later rise in frequency. Finally, although ARS-specific precursor cells are present in high frequency at birth, CRIA-positive monoclonal anti-ARS antibodies are not observ...Continue Reading
References
Oct 1, 1976·European Journal of Immunology·J L Claflin
Jan 1, 1978·The Journal of Experimental Medicine·M P CancroN R Klinman
Dec 1, 1979·The Journal of Experimental Medicine·K Bottomly, D E Mosier
Mar 1, 1977·The Journal of Experimental Medicine·S JuA Nisonoff
Oct 1, 1977·The Journal of Experimental Medicine·N H SigalN R Klinman
Aug 1, 1978·European Journal of Immunology·R Woodland, H Cantor
Dec 1, 1979·European Journal of Immunology·M RethK Rajewsky
Sep 1, 1976·Immunochemistry·A A KapsalisA Nisonoff
Aug 1, 1972·The Journal of Experimental Medicine·N R Klinman
Jan 1, 1973·European Journal of Immunology·D A HartA Nisonoff
Dec 1, 1981·European Journal of Immunology·Y Ben-NeriahD Givol
Feb 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·A Marshak-RothsteinM L Gefter
Apr 1, 1980·The Journal of Experimental Medicine·P EstessJ D Capra
May 1, 1980·The Journal of Experimental Medicine·K E SteinW E Paul
Jul 1, 1981·Cell·S CrewsL Hood
May 1, 1981·The Journal of Experimental Medicine·J D CongerJ W Goodman
Nov 1, 1981·European Journal of Immunology·J F KearneyJ Quintáns
Jan 28, 1982·Nature·J A OwenN R Klinman
Jul 1, 1981·European Journal of Immunology·A Marshak-RothsteinM L Gefter
Nov 1, 1981·The Journal of Experimental Medicine·C M AndresJ L Claflin
Citations
Sep 1, 1989·Molecular Immunology·F MertensM Slaoui
May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S K DattaR S Schwartz
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·R I NearM L Gefter
Jan 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K S HathcockR J Hodes
Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·D TeitelbaumR Arnon
Jul 1, 1983·The Journal of Experimental Medicine·M A ThompsonM P Cancro
Aug 1, 1983·The Journal of Experimental Medicine·J D CongerJ W Goodman
Jul 1, 1984·The Journal of Experimental Medicine·M SlaouiJ Urbain
Oct 1, 1984·The Journal of Experimental Medicine·K MeekJ D Capra
Jan 1, 1985·The Journal of Experimental Medicine·P V Hornbeck, G K Lewis
Apr 1, 1985·The Journal of Experimental Medicine·S Raychaudhuri, M P Cancro
Jun 1, 1985·The Journal of Experimental Medicine·M S SyB Benacerraf
Nov 1, 1985·The Journal of Experimental Medicine·B G Froscher, N R Klinman
Nov 1, 1987·The Journal of Experimental Medicine·T ManserM L Gefter
Jul 1, 1989·The Journal of Experimental Medicine·K D MeekJ D Capra
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M MoserJ Urbain
Apr 1, 1986·Immunological Reviews·M SlaouiJ Urbain
Sep 1, 1988·Scandinavian Journal of Immunology·A GayaJ Vives
Apr 1, 1985·Arthritis and Rheumatism·M R LieblingJ Radosevich
Feb 1, 1989·Infection and Immunity·M J FultzE S Metcalf
Dec 14, 1984·Science·T ManserM L Gefter