Regulation of B-cell function by NF-kappaB c-Rel in health and disease.

Cellular and Molecular Life Sciences : CMLS
Shrikanth C Basavarajappa, Parameswaran Ramakrishnan

Abstract

B cells mediate humoral immune response and contribute to the regulation of cellular immune response. Members of the Nuclear Factor kappaB (NF-κB) family of transcription factors play a major role in regulating B-cell functions. NF-κB subunit c-Rel is predominantly expressed in lymphocytes, and in B cells, it is required for survival, proliferation, and antibody production. Dysregulation of c-Rel expression and activation alters B-cell homeostasis and is associated with B-cell lymphomas and autoimmune pathologies. Based on its essential roles, c-Rel may serve as a potential prognostic and therapeutic target. This review summarizes the current understanding of the multifaceted role of c-Rel in B cells and B-cell diseases.

References

Oct 1, 1991·Trends in Genetics : TIG·T D Gilmore
Feb 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·S DoerreW C Greene
Oct 29, 1998·British Journal of Haematology·K ClodiA Younes
Dec 18, 1998·The Journal of Biological Chemistry·E ChenC C Li
Dec 22, 1998·Molecular and Cellular Biology·C V Dang
Jun 23, 2000·The Journal of Clinical Investigation·I K CampbellI P Wicks
Oct 24, 2000·Immunological Reviews·R GugasyanS Gerondakis
Jul 19, 2001·Nature·A M ReimoldL H Glimcher
Aug 18, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·F D ShiN Sarvetnick
Oct 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A M OwyangH C Liou
Apr 10, 2002·The Journal of Allergy and Clinical Immunology·Mark Ballow
Jul 31, 2002·International Immunology·Constance Y HsiaHsiou-Chi Liou
Nov 7, 2002·Molecular Cell·Joel L Pomerantz, David Baltimore
Mar 14, 2003·Current Opinion in Immunology·Amy L Kenter
Jul 2, 2003·Nature Immunology·Tetsuo Yamazaki, Tomohiro Kurosaki
Dec 4, 2004·The Journal of Clinical Investigation·Ashish JainJonathan M J Derry

❮ Previous
Next ❯

Methods Mentioned

BETA
ubiquitination

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.