Regulation of B cell immunoglobulin secretion by functional subsets of T lymphocytes in man

European Journal of Immunology
E L ReinherzS F Schlossman

Abstract

Two distinct immunoregulatory T cell subsets, termed T4+ and T5+, have been defined in man by monoclonal antibodies. Prior studies have shown that the T4+ T cell population provided help for B cell immunoglobulin (Ig) production and was required for generation of T5+ cytotoxic effector cells. In the present study, the regulatory effects of the T5+ T cell subset on B cell Ig secretion were determined in a pokeweed mitogen-driven system. It was found that the T5+ subset, in contrast to the T4+ subset, was incapable of providing help to B cells and, more importantly, could suppress Ig secretion by B cells in the presence of T4+ inducer T cells, Given earlier studies demonstrating that the T5+ T cell subset suppressed T cell responses as well, this population appears to represent the major suppressor subset in man for T-T and T-B interactions.

References

May 10, 1979·The New England Journal of Medicine·E L ReinherzS F Schlossman
Nov 8, 1979·The New England Journal of Medicine·E L ReinherzS F Schlossman
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E L ReinherzS F Schlossman
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·E L ReinherzS F Schlossman
Apr 1, 1980·Cell·E L Reinherz, S F Schlossman

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Citations

Jan 1, 1982·Springer Seminars in Immunopathology·M C MingariL Moretta
Jan 1, 1984·Springer Seminars in Immunopathology·S F Schlossman, E L Reinherz
Feb 1, 1984·Journal of Reproductive Immunology·R T CheneyD T Rowlands
Aug 1, 1983·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S StroberH S Kaplan
Feb 1, 1995·Zygote : the Biology of Gametes and Early Embryos·M W GuoT Mori
Apr 2, 1981·The New England Journal of Medicine·E L ReinherzS F Schlossman
Dec 23, 1982·The New England Journal of Medicine·W C Van VoorhisZ A Cohn
Apr 25, 1985·The New England Journal of Medicine·O Acuto, E L Reinherz
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·E L ReinherzS F Schlossman
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·L M RoseE A Clark
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·U MoebiusE L Reinherz
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·U MoebiusE L Reinherz
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Dec 9, 2014·Frontiers in Immunology·Ellis L Reinherz

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