Regulation of Bax/mitochondria interaction by AKT

FEBS Letters
Lilit SimonyanStéphen Manon

Abstract

Bax-dependent mitochondrial permeabilization during apoptosis is controlled by multiple factors, including the phosphorylation by the protein kinase AKT. We used the heterologous co-expression of human Bax and AKT1 in yeast to investigate how the kinase modulates the different steps underlying Bax activation. We found that AKT activated Bax and increased its cellular content. Both effects were dependent on Ser184, but a phosphorylation of this residue did not fully explain the effects of AKT. Additional experiments with mutants substituted on Ser184 suggested that the regulation of Bax dynamic equilibrium between the cytosol and mitochondria might be more tightly regulated by Bcl-xL when Bax is phosphorylated.

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Citations

Apr 27, 2016·Mechanisms of Ageing and Development·Thibaud T RenaultStéphen Manon
Mar 23, 2017·Biochimica Et Biophysica Acta. Biomembranes·Lilit SimonyanStéphen Manon
Jan 11, 2019·Journal of Cellular Biochemistry·Gulsah AlbayrakIrem Dogan Turacli
Jan 19, 2018·Journal of the American Society of Nephrology : JASN·Dong ZhouYouhua Liu
Jun 12, 2017·Journal of Molecular Neuroscience : MN·Songyun DengLina Zhang
Feb 20, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wanatchaporn ArunmaneeChatchai Chaotham
Dec 12, 2020·Nutrition and Cancer·Connor ChestnutShrikant Anant
May 1, 2021·International Journal of Molecular Sciences·Akandé Rouchidane EyitayoStéphen Manon

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