PMID: 4080608Sep 1, 1985

Regulation of biosynthesis and release of pars intermedia peptides in Rana ridibunda: dopamine affects both acetylation and release of alpha-MSH

Peptides
Bruce G JenksH Vaudry

Abstract

Dopamine is likely an important physiological melanotropin release-inhibiting factor in amphibians. This study concerns the effects of dopamine on the biosynthesis and release of peptides from the pars intermedia of the frog Rana ridibunda. Our results show that this secretagogue has no immediate effects on either the rate of biosynthesis of pro-opiomelanocortin nor on the direction of processing of this prohormone. Pulse-chase experiments revealed that dopamine inhibited the release of all newly synthesized POMC-related peptides in a dose-dependent manner. For each dopamine concentration tested, the degree of inhibition exerted on the release of the various newly synthesized peptides by a given concentration of secretagogue was approximately the same, with the exception of that found for the alpha-MSH related peptides. Analysis of the release of these melanotropins was complex because dopamine not only inhibited their release but also, either directly or indirectly, inhibited the acetylation reaction which converts des-N alpha-acetyl alpha-MSH to alpha-MSH. Dopamine was shown to be less potent in inhibiting the release of des-N alpha-acetyl alpha-MSH than inhibiting release of the acetylated form of the peptide. In amphibians ...Continue Reading

References

Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R G AllenC B Pert
Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·S Zakarian, D G Smyth
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·N C BirnbergE Herbert
Jan 1, 1983·Cold Spring Harbor Symposia on Quantitative Biology·J L RobertsC E Gee
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·C L ChenJ L Roberts

Citations

May 1, 1989·Brain Research. Molecular Brain Research·S JégouH Vaudry
Apr 14, 1999·Life Sciences·R M Vazquez-MartinezF Gracia-Navarro
Dec 24, 1997·Comparative Biochemistry and Physiology. Part A, Physiology·Eric W Roubos
Jul 1, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Craig H WardenBertrand Perroud
May 31, 1993·Annals of the New York Academy of Sciences·Eric W RoubosBruce G Jenks
Jun 18, 1998·Annals of the New York Academy of Sciences·J R LiesteEric W Roubos
Mar 29, 2007·Neuroendocrinology·Bruce G JenksEric W Roubos
Jul 29, 2004·Proceedings of the National Academy of Sciences of the United States of America·Li GuoChristian Bjørbaek
Jan 1, 1987·Peptides·B M Verburg-van KemenadeS Saint-Pierre
Nov 1, 1987·General and Comparative Endocrinology·R M DoresM E Rothenberg
Jun 1, 1991·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·M LamaczH Vaudry
Jan 14, 1999·Endocrinology·J L Gonzalez de AguilarF Gracia-Navarro

Related Concepts

Acetylation
Intropin
Melanocyte stimulating hormone
Pituitary Stalk
Opiocortin
Rana ridibunda

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