Regulation of blood flow distribution in skeletal muscle: role of erythrocyte-released ATP.

The Journal of Physiology
Mary L Ellsworth, Randy S Sprague

Abstract

The maintenance of adequate tissue O(2) levels in skeletal muscle is vital for normal physiology and requires a well regulated and appropriately distributed convective O(2) supply. Inherent in this fundamental physiological process is the requirement for a mechanism which both senses tissue O(2) need and locally adjusts flow to appropriately meet that need. Over the past several years we and others have suggested that, in skeletal muscle, O(2) carrying erythrocytes participate in the regulation of total blood flow and its distribution by releasing ATP. Importantly, the release of this vasoactive molecule must be both rapid and well controlled if it is to serve an important physiological role. Here we provide insights into three distinct regulated signalling pathways within the erythrocyte that are activated by exposure to reduced O(2) tension or in response to binding of agonists to the prostacyclin or β-adrenergic receptors. Although much has been learned about the role of the erythrocyte in perfusion of skeletal muscle, much remains to be understood. However, what is clear is that the long established passive carrier of O(2) also contributes to the regulation of the distribution of microvascular perfusion in skeletal muscle b...Continue Reading

References

Apr 23, 1976·Biochimica Et Biophysica Acta·S B RodanR I Sha'afi
Mar 1, 1990·The American Journal of Physiology·A Koller, G Kaley
Oct 1, 1993·Journal of Applied Physiology·J C Stein, M L Ellsworth
Dec 1, 1995·The American Journal of Physiology·M L EllsworthH H Dietrich
Apr 1, 1997·The American Journal of Physiology·W T McCulloughM L Ellsworth
Jul 31, 1998·Microvascular Research·D M CollinsM L Ellsworth
Nov 14, 1998·The American Journal of Physiology·R S SpragueA J Lonigro
Jan 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·T OsanaiK Okumura
Apr 6, 2000·American Journal of Physiology. Heart and Circulatory Physiology·H H DietrichR G Dacey
Apr 12, 2000·Acta Physiologica Scandinavica·M L Ellsworth
May 18, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J E JaggerC G Ellis
Sep 8, 2001·American Journal of Physiology. Cell Physiology·R S SpragueA J Lonigro
Nov 15, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Jeffrey J OlearczykRandy S Sprague
Apr 10, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Jeffrey J OlearczykRandy S Sprague
Dec 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Muriel NoblesAndrew Tinker
Mar 24, 2006·Nature·David C GadsbyLászló Csanády
Dec 22, 1914·The Journal of Physiology·C G Wolf, J Barcroft
Jun 25, 2008·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Randy S SpragueAlan H Stephenson
Jul 1, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Madelyn S HansonRandy S Sprague
Oct 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jiandi WanHoward A Stone
Mar 3, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Shaquria P AdderleyRandy S Sprague
Apr 15, 2009·Physiology·Mary L EllsworthRandy S Sprague
Dec 17, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Shaquria P AdderleyRandy S Sprague
Jun 1, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Randy S SpragueMary L Ellsworth
Jul 14, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Meera SridharanRandy S Sprague
Jul 16, 2010·Pharmacological Reports : PR·Shaquria P AdderleyMadelyn S Hanson
Aug 5, 2010·Experimental Biology and Medicine·Meera SridharanAlan H Stephenson
Dec 21, 2010·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Shaquria P AdderleyMary L Ellsworth
Apr 29, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Shaquria P AdderleyRandy S Sprague
Jun 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Alison M ForsythHoward A Stone
Dec 14, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Meera SridharanRandy S Sprague

❮ Previous
Next ❯

Citations

Dec 25, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Joshua T ButcherJefferson C Frisbee
Mar 19, 2013·Future Medicinal Chemistry·Charles KennedyAsrin Tengah
Jul 13, 2013·European Journal of Applied Physiology·Masashi IchinoseTakeshi Nishiyasu
Jun 26, 2014·European Journal of Applied Physiology·S P MortensenM H Laughlin
Oct 3, 2012·The Journal of Physiology·Jose A L Calbet, Carsten Lundby
Oct 10, 2012·The Journal of Physiology·Janice M Marshall, Clare J Ray
Oct 20, 2012·The Journal of Physiology·José González-Alonso
Nov 4, 2015·Nitric Oxide : Biology and Chemistry·Patrick KirbyDov Jaron
Sep 1, 2015·The Journal of Physiology·Coral L Murrant, Ingrid H Sarelius
May 17, 2012·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Christopher G EllisDaniel Goldman
Nov 22, 2015·Scandinavian Journal of Medicine & Science in Sports·M NybergY Hellsten
Jun 8, 2013·Biochimica Et Biophysica Acta·María Florencia Leal DenisPablo J Schwarzbaum
Feb 5, 2014·Redox Biology·Miriam M Cortese-Krott, Malte Kelm
Aug 7, 2014·Blood·Jacek SikoraRyszard Grygorczyk
Jun 30, 2016·PloS One·M Florencia Leal DenisPablo J Schwarzbaum
Dec 31, 2016·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Coral L MurrantNicole M Novielli
Aug 31, 2018·Diabetes/metabolism Research and Reviews·Michelle Teodoro AlvesKarina Braga Gomes
Dec 20, 2018·The Journal of Biological Chemistry·Suilan ZhengPhilip S Low
Jun 15, 2019·International Journal of Molecular Sciences·Denis RevskijManfred Mielenz
Oct 4, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jennifer P RichardsRandy S Sprague
Aug 1, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jennifer P RichardsRandy S Sprague
Dec 18, 2013·Pharmacological Reviews·Geoffrey Burnstock, Vera Ralevic
Apr 8, 2015·The Journal of Biological Chemistry·Tiziana VigliaroloElena Zocchi
Jul 3, 2015·Physiology·Gina L C Yosten, Grant R Kolar
Feb 26, 2015·American Journal of Physiology. Endocrinology and Metabolism·Ping HuMaria B Grant
Nov 9, 2016·Aging·Gwenael LayecRussell S Richardson
Jun 21, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Willis K Samson
May 31, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Peter M ChristensenJens Bangsbo
Mar 27, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Clare E Thorn, Angela C Shore

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.