Regulation of Bone Metabolism by Serotonin

Advances in Experimental Medicine and Biology
Brigitte LavoieGary M Mawe

Abstract

The processes of bone growth and turnover are tightly regulated by the actions of various signaling molecules, including hormones, growth factors, and cytokines. Imbalances in these processes can lead to skeletal disorders such as osteoporosis or high bone mass disease. It is becoming increasingly clear that serotonin can act through a number of mechanisms, and at different locations in the body, to influence the balance between bone formation and resorption. Its actions on bone metabolism can vary, based on its site of synthesis (central or peripheral) as well as the cells and subtypes of receptors that are activated. Within the central nervous system, serotonergic neurons act via the hypothalamus to suppress sympathetic input to the bone. Since sympathetic input inhibits bone formation, brain serotonin has a net positive effect on bone growth. Gut-derived serotonin is thought to inhibit bone growth by attenuating osteoblast proliferation via activation of receptors on pre-osteoblasts. There is also evidence that serotonin can be synthesized within the bone and act to modulate bone metabolism. Osteoblasts, osteoclasts, and osteocytes all have the machinery to synthesize serotonin, and they also express the serotonin-reuptake t...Continue Reading

Citations

Feb 18, 2018·Calcified Tissue International·Laura R McCabe, Narayanan Parameswaran
Oct 24, 2018·American Journal of Physiology. Endocrinology and Metabolism·Samantha R WeaverLaura L Hernandez
Aug 31, 2019·European Journal of Clinical Pharmacology·Quentin DardonvilleHaleh Bagheri
Jun 20, 2020·Probiotics and Antimicrobial Proteins·Deon P Neveling, Leon M T Dicks
Aug 6, 2018·Biochimie·Anne BaudryOdile Kellermann
Jun 3, 2021·Animals : an Open Access Journal From MDPI·Sha JiangHeng-Wei Cheng
Aug 8, 2021·International Journal of Molecular Sciences·Ning LiuXiaoyu Wang

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