Regulation of brown fat by AMP-activated protein kinase

Trends in Molecular Medicine
Andrea D van DamMariëtte R Boon

Abstract

Novel strategies are needed to reduce the obesity epidemic. One promising strategy is activation of brown adipose tissue (BAT), either via the brain or directly, which increases energy expenditure by combustion of fatty acids (FAs) into heat. The enzyme complex AMP-activated protein kinase (AMPK) is crucially involved in energy metabolism and is highly expressed in both brain and BAT, regulating thermogenesis. As a general rule, BAT activity and energy expenditure are increased either by suppression of AMPK activity in the brain, resulting in enhanced sympathetic outflow towards BAT, or by activation of AMPK in BAT. Targeting AMPK may thus hold therapeutic potential for the treatment of obesity and related disorders.

References

Jul 1, 1997·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·C MüllerL Tappy
Nov 22, 2002·Proceedings of the National Academy of Sciences of the United States of America·Haihong ZongGerald I Shulman
Aug 12, 2003·Nature Genetics·Zhihong ZhouPeng Li
Nov 15, 2003·Current Biology : CB·Angela WoodsDavid Carling
Jan 13, 2004·Physiological Reviews·Barbara Cannon, Jan Nedergaard
Mar 17, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·P SchrauwenM K C Hesselink
Apr 17, 2004·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·C FilozofA Fernández-Cruz
Jun 28, 2005·The Journal of Biological Chemistry·Rebecca L HurleyLee A Witters
Jul 20, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·T YamanouchiT Kawasaki
Sep 2, 2005·Molecular and Cellular Biology·Bingzhong XueLeslie P Kozak
Dec 6, 2006·The New England Journal of Medicine·Steven E KahnUNKNOWN ADOPT Study Group
Jul 27, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A Golay
Feb 12, 2008·The American Journal of Medicine·Shelley R SalpeterEdwin E Salpeter
Sep 18, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·D G Hardie
Feb 28, 2009·Acta Physiologica·N L Dzamko, G R Steinberg
Apr 10, 2009·The New England Journal of Medicine·Wouter D van Marken LichtenbeltG J Jaap Teule
Jul 9, 2009·Physiological Reviews·Gregory R Steinberg, Bruce E Kemp
Nov 28, 2009·The EMBO Journal·Nabil DjouderWilhelm Krek
Jan 1, 2008·Obesity Facts·Annika HerwigPerry Barrett
Aug 31, 2010·Nature Medicine·Miguel LópezAntonio Vidal-Puig
Jan 7, 2011·The Journal of Biological Chemistry·Thomas PulinilkunnilBarbara B Kahn
Apr 15, 2011·Trends in Endocrinology and Metabolism : TEM·Joseph S MarinoJennifer W Hill
Jun 7, 2011·Cell Metabolism·Maryam AhmadianHei Sook Sul
Aug 26, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Pablo J EnrioriMichael A Cowley
Feb 9, 2012·Diabetes·Pablo B Martínez de MorentinMiguel López
Jul 4, 2012·Circulation·James O HillJohn C Peters

❮ Previous
Next ❯

Citations

Mar 30, 2016·Current Opinion in Lipidology·Maaike SchilperoortPatrick C N Rensen
May 21, 2016·Nature Reviews. Endocrinology·Miguel LópezCarlos Diéguez
Jan 5, 2018·The Journal of Clinical Endocrinology and Metabolism·Jane NaufahuRichard W A Mackenzie
Jun 4, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Jian CaoNader G Abraham
Sep 5, 2018·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yan LiAtsushi Takahashi
Jun 25, 2020·Adipocyte·Jianmei ZhangJiajun Zhao
Dec 29, 2017·Biological Reviews of the Cambridge Philosophical Society·Anutosh Chakraborty
May 7, 2020·Frontiers in Endocrinology·Maaike E StraatMariëtte R Boon
Apr 10, 2020·Environmental Science and Pollution Research International·Liying SongJinzhuo Zhao
May 28, 2020·Frontiers in Molecular Biosciences·Bilal AhmadEng Hwa Wong
Jun 28, 2018·Nutrition & Metabolism·Janaiya S SamuelsSrujana Rayalam
Oct 20, 2020·Frontiers in Endocrinology·Hailan LiuFang Hu
Aug 3, 2019·European Journal of Medicinal Chemistry·Lucia BiasuttoMario Zoratti
Apr 13, 2021·Frontiers in Pharmacology·Xuelian ZhangXiaobo Sun
Jun 3, 2021·Cells·Jamie I van der VaartRiekelt H Houtkooper
Feb 16, 2017·Science Signaling·Aliki PerdikariChristian Wolfrum

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved