PMID: 8584423Jan 1, 1996Paper

Regulation of Ca channel by intracellular Ca2+ and Mg2+ in frog ventricular cells

Pflügers Archiv : European journal of physiology
K Yamaoka, I Seyama

Abstract

The effects of changing the intracellular concentrations of Ca2+ or Mg2+ ([Ca2+]i, [Mg2+]i) on Ca current (ICa) was studied in frog ventricular myocytes using the whole-cell and cell-attached patch clamp techniques. In the physiological range of [Mg2+]i an increase in [Ca2+]i enhanced ICa whereas at lower [Mg2+]i ICa was suppressed. The increase in ICa caused by Ca2+ loading was not mediated by phosphorylation since the kinase inhibitors H-8 ¿N-[2-(methylamino)-ethyl]-5-isoquinolinesulphonamide dihydrochloride¿, staurosporine and KN-62 ¿1-[N,O-bis(5-isoquinolinesulphonyl)-N-methyl-1-tyrosyl]-4- phenylpiperizine¿ and a non-hydrolysable adenosine 5'-triphosphate analogue beta,gamma-methyleneadenosine 5'-triphosphate did not prevent the Ca2+-induced ICa increase. ICa was dramatically increased from 10+/-6 (n=4) to 71+/-7 nA/nF (n=4) when [Mg2+]i was lowered from 1.0 x 10(-3) to 1.0 x 10(-6) M at a [Ca2+]i of 10(-8) M. The concentration response relation for inhibition of Ca channels by [Mg2+]i is modulated by [Ca2+]i. To account for the experimental results it is postulated that competitive binding of Ca2+ or Mg2+ to the Ca channel accelerates the transition of the channel from an active to a silent mode. Single-channel recordings...Continue Reading

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Citations

Oct 24, 1998·British Journal of Pharmacology·N SakamotoH Nakaya
Oct 22, 2010·Genome Génome / Conseil National De Recherches Canada·Dechassa DuressaDongquan Chen
Dec 15, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Alvaro YogiRhian M Touyz
Feb 24, 2001·Critical Care Clinics·M S Agus, Z S Agus
Nov 18, 2003·The Journal of Physiology·Min WangJoshua R Berlin
Feb 17, 2006·American Journal of Physiology. Cell Physiology·Min Wang, Joshua R Berlin
Nov 23, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Yin-Tie JinKenjiro Kikuchi
Sep 15, 2001·American Journal of Physiology. Heart and Circulatory Physiology·S PelzerD J Pelzer
Jul 1, 1996·Pflügers Archiv : European journal of physiology·K Yamaoka, I Seyama
Feb 9, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Kaoru YamaokaIssei Seyama
Sep 19, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Jin ZhangDonald R Matteson
Mar 5, 1998·The American Journal of Physiology·M YoshimuraG Kajiyama
Apr 3, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Julio Altamirano, Donald M Bers
Nov 25, 2006·Archives of Biochemistry and Biophysics·Kanigula MubagwaRegina Macianskiene

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