PMID: 7011391Jan 8, 1981Paper

Regulation of calcium fluxes in rat pancreatic islets. Quinine mimics the dual effect of glucose on calcium movements

Biochimica Et Biophysica Acta
A HerchuelzW J Malaisse

Abstract

The effects of quinine and 9-aminoacridine, two blockers of potassium conductance in islet cells, on 45Ca efflux and insulin release from perifused islets were investigated in order to elucidate the mechanisms by which glucose initially reduces 45Ca efflux and later stimulates calcium inflow in islet cells. In the absence of glucose, 100 microM quinine stimulated 45Ca net uptake, 45Ca outflow rate and insulin release. Quinine also dramatically enhanced the cationic and the secretory response to intermediate concentrations of glucose, but had little effect on 45Ca net uptake, 45Ca fractional outflow rate and insulin release at a high glucose concentration (16.7 mM). The ability of quinine to stimulate 45Ca efflux depended on the presence of extracellular calcium, suggesting that it reflects a stimulation of calcium entry in the islet cells. In the absence of extracellular calcium, quinine provoked a sustained decrease in 45Ca efflux. Such an inhibitory effect was not additive to that of glucose, and was reduced at low extracellular Na+ concentration. At a low concentration (5 microM), quinine, although reducing 86Rb efflux from the islets to the same extent as a non-insulinotropic glucose concentration (4.4 mM), failed to inhibi...Continue Reading

Citations

Dec 16, 1986·European Journal of Pharmacology·W OkitolondaJ C Henquin
Jan 1, 1989·Pharmacology & Therapeutics·C J BaileyV Marks
Aug 14, 1998·General Pharmacology·L LadrièreW J Malaisse
Jul 14, 1983·The New England Journal of Medicine·N J WhiteR C Turner
Jan 1, 1991·Annals of the New York Academy of Sciences·A Herchuelz, P O Plasman
Oct 15, 1984·Experientia·W J MalaisseA Sener
May 1, 1993·The Journal of Emergency Medicine·J E Bodenhamer, M J Smilkstein
Jul 16, 1982·Biochemical and Biophysical Research Communications·P LebrunA Herchuelz
May 16, 1988·Biochemical and Biophysical Research Communications·P LebrunA Herchuelz
Oct 1, 1982·Journal of Cellular Physiology·A Holian, R P Daniele
Apr 1, 2010·Journal of Nutritional Science and Vitaminology·Hanae YamazakiWalter S Zawalich
Jul 1, 1986·Journal of the Royal Society of Medicine·R G JonesP Quirke
Oct 1, 1988·The American Journal of Physiology·P BergstenB Hellman
Nov 1, 1983·The American Journal of Physiology·T Andersson
May 1, 1985·The American Journal of Physiology·P LebrunA Herchuelz

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