PMID: 9551852Apr 29, 1998Paper

Regulation of calcium influx and phospholipase C activity by indoleamines in dinoflagellate Crypthecodinium cohnii

Journal of Pineal Research
S T TsimY H Wong

Abstract

Exogenous indoleamines such as melatonin and 5-methoxytryptamine have been shown to induce cyst formation (encystment) in many species of dinoflagellate. Induction of inositol phosphates formation by indoleamine has previously been demonstrated in Crypthecodinium cohnii. In addition, depletion of extracellular Ca2+ blocks the indoleamine-induced encystment. In the present study, 12 indoleamines (including melatonin and related compounds) were examined for their abilities to induce Ca2+ influx, inositol phosphates formation, and encystment in C. cohnii. The results showed that melatonin, 5-methoxytryptamine, and the peptide toxin mastoparan stimulated 45Ca2+ influxes in dose- and time-dependent manners. The EC50 values of 5-methoxytrypramine and mastoparan to stimulate 45Ca2+ uptake were 2 mM and 35 microM, respectively. The 5-methoxytryptamine- and mastoparan-induced 45Ca2+ influx were partially attenuated by the calcium channel blockers, verapamil and ruthenium red. A series of indoleamines were examined for their structure-activity relationship on the induction of encystment and formation of inositol phosphates. Melatonin-induced inositol phosphates formation was completely blocked by U73122, indicating the possible involveme...Continue Reading

References

Jun 1, 1992·Experimental Parasitology·H S OzS A Morris
Dec 1, 1991·Current Opinion in Genetics & Development·M L Sogin
Nov 7, 1991·Nature·K MoriyoshiS Nakanishi
Jan 1, 1991·Journal of Neural Transmission. General Section·R E RosensteinD P Cardinali
Jul 1, 1990·Neuropeptides·A SalamanW I Silva
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P WitzR Hen
Jan 1, 1989·General Pharmacology·S ShibataH Usui
Sep 1, 1988·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M L Dubocovich
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M L Dubocovich, J S Takahashi
Feb 1, 1972·The Journal of protozoology·S BanerjeeL Margulis
Oct 1, 1995·Physiological Reviews·K Wickman, D E Clapham
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·T EbisawaS M Reppert
Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·S M ReppertJ F Gusella
Feb 1, 1995·British Journal of Pharmacology·D SugdenD F Lewis
Feb 1, 1995·Trends in Pharmacological Sciences·M L Dubocovich
Jan 1, 1995·Journal of Neurochemistry·J S Popova, M L Dubocovich
Nov 1, 1993·The Journal of Eukaryotic Microbiology·R ChiesaF L Renaud
Jan 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·K S SugamoriH H Van Tol
Mar 1, 1994·Trends in Pharmacological Sciences·C FasolatoT Pozzan
Aug 1, 1996·Journal of Neurochemistry·M P FaillaceR E Rosenstein
May 23, 1996·European Journal of Pharmacology·C NavajasJ T Laitinen

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Citations

Jun 15, 2005·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Joseph T Y Wong, Alvin C M Kwok
Apr 22, 2003·Journal of Neuroscience Research·Y El-SherifA Wieraszko
Nov 11, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Piero BagnaresiCélia R S Garcia
Apr 15, 2005·Plant & Cell Physiology·Connie M C LamJoseph T Y Wong
Mar 29, 2003·Journal of Pineal Research·Rüdiger Hardeland, Burkhard Poeggeler
Apr 30, 2020·Journal of Phycology·Gaspard DelebecqRaffaele Siano
Jan 11, 2021·European Journal of Protistology·Sofia AbassiJang-Seu Ki

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