PMID: 9178610Jun 1, 1997Paper

Regulation of cation-selective channels in liver cells

The Journal of Membrane Biology
S D LidofskyJ G Fitz

Abstract

In liver cells, cation-selective channels are permeable to Ca2+ and have been postulated to represent a pathway for receptor-mediated Ca2+ influx. This study examines the mechanisms involved in the regulation of these channels in a model liver cell line. Using patch-clamp recording techniques, it is shown that channel open probability is a saturable function of cytosolic [Ca2+], with half-maximal opening at 660 nm. By contrast, channel opening is not affected by membrane voltage or cytosolic pH. In intact cells, reduction of cytosolic [Cl-], a physiological response to Ca2+-mobilizing hormones and cell swelling, is also associated with an increase in channel opening. Finally, channel opening is inhibited by intracellular ATP through a mechanism that does not involve ATP hydrolysis. These findings suggest that opening of cation-selective channels is coupled to the metabolic state of the cell and provides a positive feedback mechanism for regulation of receptor-mediated Na+ and Ca2+ influx.

Citations

Oct 2, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R M RomanJ G Fitz
Nov 21, 2001·The Journal of Clinical Investigation·A P FeranchakJ G Fitz
Nov 22, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Daniel S EmmettJ Gregory Fitz
Sep 29, 2004·Cell Calcium·Karl E O AkermanJyrki P Kukkonen
May 17, 2003·Archives of Oral Biology·Minako AbeTakashi Suzuki
Feb 23, 2008·Biochimica Et Biophysica Acta·Gregory J BarrittGrigori Y Rychkov
May 28, 2004·American Journal of Physiology. Cell Physiology·Felipe SimonAndrés Stutzin
Mar 14, 2001·American Journal of Physiology. Cell Physiology·E T BarfodS D Lidofsky
Dec 22, 1999·The American Journal of Physiology·R M RomanJ G Fitz

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