Regulation of CD1 antigen-presenting complex stability.

The Journal of Biological Chemistry
Artur N OdyniecMichael B Brenner

Abstract

For major histocompatibility complex class I and II molecules, the binding of specific peptide antigens is essential for assembly and trafficking and is at the center of their quality control mechanism. However, the role of lipid antigen binding in stabilization and quality control of CD1 heavy chain (HC).beta(2)-microglobulin (beta(2)m) complexes is unclear. Furthermore, the distinct trafficking and loading routes of CD1 proteins take them from mildly acidic pH in early endososmal compartments (pH 6.0) to markedly acidic pH in lysosomes (pH 5.0) and back to neutral pH of the cell surface (pH 7.4). Here, we present evidence that the stability of each CD1 HC.beta(2)m complex is determined by the distinct pH optima identical to that of the intracellular compartments in which each CD1 isoform resides. Although stable at acidic endosomal pH, complexes are only stable at cell surface pH 7.4 when bound to specific lipid antigens. The proposed model outlines a quality control program that allows lipid exchange at low endosomal pH without dissociation of the CD1 HC.beta(2)m complex and then stabilizes the antigen-loaded complex at neutral pH at the cell surface.

References

Mar 1, 1979·European Journal of Immunology·A J McMichaelC Milstein
Jul 27, 1990·Cell·A TownsendA Tse
Aug 2, 1990·Nature·H G LjunggrenK Kärre
Jan 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·L M SmithH M McConnell
Apr 7, 1998·Immunity·W A ErnstR L Modlin
Oct 23, 1998·The Journal of Experimental Medicine·F M SpadaS A Porcelli
Jan 5, 1999·The Journal of Experimental Medicine·E P GrantM B Brenner
Jan 8, 2000·Immunity·M SugitaM B Brenner
Mar 14, 2000·Immunity·J E GumperzS M Behar
Jul 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·M SugitaM B Brenner
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A MeliánS A Porcelli
Nov 28, 2000·European Journal of Immunology·F M SpadaS A Porcelli
Jan 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·A Dharshan De SilvaSebastian Joyce
Jun 7, 2002·Immunity·Masahiko SugitaMichael B Brenner
Sep 20, 2002·The Journal of Biological Chemistry·Suk-Jo Kang, Peter Cresswell
Oct 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Manuela CernadasMichael B Brenner
Jan 13, 2004·Nature Immunology·Suk-Jo Kang, Peter Cresswell
Jan 13, 2004·Nature Immunology·Florian WinauUlrich E Schaible
Jan 14, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kajsa M Paulsson, Ping Wang
Mar 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anna P LawtonMitchell Kronenberg
Jul 12, 2005·Nature Immunology·Michael KochVincenzo Cerundolo
Aug 10, 2005·The Journal of Experimental Medicine·Stephanie K DouganRichard S Blumberg
Apr 7, 2006·European Journal of Immunology·Vania ManolovaGennaro De Libero
Mar 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Weiming YuanPeter Cresswell
Jun 10, 2008·Immunity·Miguel RellosoD Branch Moody
Jun 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Elizabeth A LeadbetterMichael B Brenner
Jun 20, 2008·Traffic·Duarte C BarralMichael B Brenner
May 30, 2009·Advances in Immunology·Nadia R CohenMichael B Brenner

❮ Previous
Next ❯

Citations

Apr 26, 2013·The Journal of Biological Chemistry·Amit KuntePeter Cresswell
Nov 20, 2013·Proceedings of the National Academy of Sciences of the United States of America·Mariolina SalioVincenzo Cerundolo
Feb 7, 2014·Annual Review of Immunology·Mariolina SalioVincenzo Cerundolo
Mar 25, 2014·Cellular and Molecular Life Sciences : CMLS·Dalam Ly, D Branch Moody
Feb 22, 2012·Trends in Immunology·Gennaro De Libero, Lucia Mori
Jan 27, 2012·Annals of the New York Academy of Sciences·Sebastian Zeissig, Richard S Blumberg
Aug 19, 2015·Immunological Reviews·Annemieke de Jong
Jul 10, 2013·Cellular and Molecular Life Sciences : CMLS·M RakhshandehrooM Boes
Sep 4, 2013·Biological Chemistry·C Marie DowdsSebastian Zeissig
Aug 28, 2015·Journal of Leukocyte Biology·Giorgio CamilliRosa Sorrentino
Jul 3, 2018·Frontiers in Immunology·Marco LeporeGennaro De Libero
Sep 13, 2017·Proceedings of the National Academy of Sciences of the United States of America·Sebastian ZeissigRichard S Blumberg

❮ Previous
Next ❯

Methods Mentioned

BETA
CLIP
immunoprecipitation

Software Mentioned

ImageJ

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.