PMID: 11920590Mar 29, 2002Paper

Regulation of CD1d expression by murine tumor cells: escape from immunosurveillance or alternate target molecules?

International Journal of Cancer. Journal International Du Cancer
Tim FiedlerMarkus J Maeurer

Abstract

alpha beta+ TCR T cells recognize peptide fragments displayed by MHC-class I or -class II molecules. Recently, additional mechanisms of antigen recognition by T cells have been identified, including CD1-mediated presentation of nonpeptide antigens. Only a limited number of CD1 antigens is retained in the mouse, i.e., the group II CD1 antigens, which are split into CD1D1 and CD1d2. Several T cell subsets have been shown to interact with murine CD1 antigens, including NK cells or "natural T cells" with the invariant V alpha 14 J alpha 281 TCR chain. Even if TAP defects may prevent classical endogenous antigen presentation in tumor cell lines, antigen presentation via CD1 is still functional. Therefore, CD1-mediated recognition of transformed cells by NK cells or "natural T cells" may represent an alternative way for immune surveillance. CD1 cell surface expression in murine tumor cell lines of different histology, including the B cell lymphoma A20, macrophage cell lines J774 and P388D1, mastocytoma P815, thymoma EL-4, melanoma B16, colon adenocarcinoma MC-38 and renal carcinoma Renca is regulated by Th1- (IFN-gamma), Th2- (IL-4, IL-10 and vIL-10) or GM-CSF (Th1/Th2) cytokines, depending on the tumor histology. In order to disting...Continue Reading

References

Nov 2, 1990·Science·P A BleicherC Terhorst
Jul 1, 1990·Immunology Today·H G Ljunggren, K Kärre
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·L H MartinC Milstein
Jan 1, 1995·Advances in Immunology·S A Porcelli
Dec 1, 1995·The Journal of Experimental Medicine·R R BrutkiewiczA Bendelac
Jul 14, 1995·Science·A R CastañoP A Peterson
Aug 31, 1995·Advances in Colloid and Interface Science·O Söhnel, F Grases
Apr 1, 1994·The Journal of Experimental Medicine·T Yoshimoto, W E Paul
Jan 1, 1994·Annual Review of Immunology·P Matzinger
Oct 1, 1996·The Journal of Experimental Medicine·A BendelacO Lantz
Mar 1, 1997·Trends in Genetics : TIG·M KasaharaN Takahata
Jan 1, 1997·Annual Review of Immunology·A BendelacJ H Roark
Jan 1, 1997·Annual Review of Immunology·U BoehmJ C Howard
Aug 1, 1997·Current Opinion in Immunology·J K Maher, M Kronenberg
May 20, 1998·Proceedings of the National Academy of Sciences of the United States of America·T KawanoM Taniguchi
Jun 8, 1999·Annual Review of Immunology·S A Porcelli, R L Modlin
Feb 24, 2000·The Journal of Experimental Medicine·M J SmythD I Godfrey
Jun 6, 2000·The Journal of Experimental Medicine·K BenlaghaA Bendelac
Aug 23, 2000·Immunology Today·B SeligerS Ferrone
Sep 7, 2000·The Journal of Experimental Medicine·H R MacDonald

❮ Previous
Next ❯

Citations

Mar 16, 2005·Current Opinion in Immunology·Willem W Overwijk
Jun 8, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Mark A ExleySteven P Balk
Mar 11, 2004·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·B Gozalbo-LópezE Martínez-Naves
Nov 6, 2010·Immunology·Sally A Huber
Dec 8, 2004·The American Journal of Pathology·Gianni GerliniFrank O Nestle
Jan 15, 2014·Leukemia Research·Agnieszka Bojarska-JunakJacek Roliński
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sally HuberMark Exley
Jul 28, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gerhard WingenderMitchell Kronenberg
Jan 29, 2021·Journal of Immunology Research·Nilberto Dias de AraújoAllyson Guimarães Costa
Aug 19, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yuting MaMinxin Shi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.