PMID: 11604589Oct 18, 2001Paper

Regulation of CD40 ligand expression in systemic lupus erythematosus

Current Opinion in Rheumatology
M K Crow, K A Kirou

Abstract

Production of pathogenic autoantibodies in systemic lupus erythematosus (SLE) requires T cell help, along with ligation of the B cell surface immunoglobulin receptor by antigen. It is likely that macrophages, dendritic cells, and endothelial cells are also activated by interactions with T cells and contribute to lupus pathology. CD40 ligand (CD40L, CD154), a member of the tumor necrosis factor family of cell surface molecules, mediates these contact dependent signals delivered by CD4 + T helper cells to CD40 + target cells. Recent data from SLE patients and murine lupus models have demonstrated prolonged expression of CD40L on lupus T cells and its capacity to mediate excessive B cell activation. This review summarizes the current information regarding transcriptional and post-transcriptional regulation of CD40L expression in normal and SLE T cells. More complete characterization of the mechanisms that regulate the magnitude and duration of CD40L expression should suggest new approaches to modulate this promising therapeutic target.

References

Dec 1, 1992·The Journal of Experimental Medicine·M K SpriggsW C Fanslow
May 7, 1992·Nature·R J ArmitageC R Maliszewski
Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·R J NoelleA Aruffo
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·K KarmannJ S Pober
Jul 1, 1995·The Journal of Experimental Medicine·D HollenbaughA Aruffo
Aug 1, 1995·Kidney International·L BianconeI Stamenkovic
Mar 1, 1994·The Journal of Clinical Investigation·R FuleihanR S Geha
Apr 1, 1996·European Journal of Immunology·H G NüssleinB Manger
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·K GerritseE Claassen
Aug 1, 1996·The Journal of Clinical Investigation·M KoshyM K Crow
Jan 1, 1996·Annual Review of Immunology·T M FoyR J Noelle
Aug 1, 1997·International Immunology·C H CleggD Hollenbaugh
Apr 1, 1998·European Journal of Immunology·M WykesD Gray
May 23, 1998·Annual Review of Immunology·I S Grewal, R A Flavell
Feb 5, 1999·Clinical and Experimental Immunology·S Hirohata
Oct 8, 1999·The Journal of Clinical Investigation·K KatoT J Kipps
Nov 5, 1999·Nature Medicine·E LutgensR A Flavell
Nov 24, 1999·Journal of the Neurological Sciences·C S ConstantinescuA M Rostami
Jan 7, 2000·The American Journal of Pathology·U SchönbeckP Libby

❮ Previous
Next ❯

Citations

Feb 1, 2011·Cellular & Molecular Immunology·Francesca MedaCarlo Selmi
May 5, 2004·The Journal of Rheumatology·Yasmeen Ahmad, Ian N Bruce
Sep 1, 2007·Current Opinion in Rheumatology·Alessandra B Pernis
Feb 5, 2013·Arthritis Research & Therapy·Dipak R Patel, Bruce C Richardson
Feb 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·A Karolina PaluckaJacques Banchereau
Apr 8, 2009·Journal of Autoimmunity·Anura Hewagama, Bruce Richardson
Jul 10, 2010·Journal of Biomedicine & Biotechnology·E Kassi, P Moutsatsou
Jun 24, 2006·The British Journal of Dermatology·A SzegediE Gyimesi
May 4, 2002·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Christina G KatsiariPetros P Sfikakis
Aug 3, 2016·The Journal of Experimental Medicine·Wen-Hsien LiuChangchun Xiao
Jul 25, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoko K TakadaYoshikazu Takada
Jul 10, 2004·Clinical and Diagnostic Laboratory Immunology·Dimitris DaoussisStamatis-Nick C Liossis
Jul 30, 2005·Arthritis and Rheumatism·Randy Q Cron
May 28, 2019·Journal of Leukocyte Biology·Camille M Syrett, Montserrat C Anguera
Aug 19, 2004·Cardiology in Review·Mohammed Abusamieh, Julia Ash
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yifang ChenLaurence Morel
Jan 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Randy Q CronMary K Crow
Oct 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qianjin LuBruce Richardson
Aug 12, 2017·Expert Review of Clinical Immunology·Matthias CassiaDavid Jayne
Jan 24, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carlos S SubausteMatthew Wessendarp
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Arpita ChoudhuryRobert A Eisenberg
Jun 20, 2018·BMJ Open Gastroenterology·Christoffer SoendergaardOle Haagen Nielsen

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.