Regulation of cell adhesion and cell sorting at embryonic boundaries

Current Topics in Developmental Biology
François Fagotto

Abstract

Embryonic boundaries are sharp delimitations that prevent intermingling between different cell populations. They are essential for the development of well-organized structures and ultimately a functional organism. It has been long believed that this process was driven by global differences in cell adhesion strength, or expression of different types of adhesion molecules. The actual picture turns out to be quite different: Boundaries should be viewed as abrupt discontinuities, where cortical contractility is acutely upregulated in response to specific cell surface contact receptors which act as repulsive cues. Cell adhesion is also modulated along the interface, in different ways depending on the type of boundary, but in all cases the process is subordinated to the function of the cortical actomyosin cytoskeleton.

Citations

Jan 23, 2016·Nature Reviews. Molecular Cell Biology·Artur Kania, Rüdiger Klein
Oct 6, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Ashley E E Bruce
Mar 9, 2018·Frontiers in Neuroscience·Florence A Giger, Corinne Houart
Aug 2, 2017·Nature Communications·Laura CantyFrançois Fagotto
Feb 16, 2021·Developmental Biology·Iain Martyn, Zev J Gartner
Jul 1, 2020·Seminars in Cell & Developmental Biology·François Fagotto
Jul 28, 2020·Seminars in Cell & Developmental Biology·François Fagotto
May 1, 2021·Soft Matter·Laura Casas-FerrerLaura Casanellas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.