Regulation of Cell Calcium and Role of Plasma Membrane Calcium ATPases

International Review of Cell and Molecular Biology
Tito CalìErnesto Carafoli

Abstract

The plasma membrane Ca2+ATPase (PMCA pump) is a member of the superfamily of P-type pumps. It has 10 transmembrane helices and 2 cytosolic loops, one of which contains the catalytic center. Its most distinctive feature is a C-terminal tail that contains most of the regulatory sites including that for calmodulin. The pump is also regulated by acidic phospholipids, kinases, a dimerization process, and numerous protein interactors. In mammals, four genes code for the four basic isoforms. Isoform complexity is increased by alternative splicing of primary transcripts. Pumps 2 and 3 are expressed preferentially in the nervous system. The pumps coexist with more powerful systems that clear Ca2+from the bulk cytosol: their role is thus the regulation of Ca2+in selected subplasma membrane microdomains, where a number of important Ca2+-dependent enzymes interact with them. Malfunctions of the pump lead to disease phenotypes that affect the nervous system preferentially.

Citations

Sep 20, 2018·Diabetes, Obesity & Metabolism·Jing W HughesDavid W Piston
Oct 2, 2019·Frontiers in Aging Neuroscience·Matthew R HolahanFernando A Oliveira
Oct 23, 2019·Cold Spring Harbor Perspectives in Biology·Malini AhujaShmuel Muallem
Dec 18, 2018·F1000Research·Giorgia PallafacchinaRosario Rizzuto
Jan 1, 2020·International Journal of Molecular Sciences·Tomasz BoczekLudmila Zylinska
Jan 10, 2019·Nature Reviews. Immunology·Mohamed Trebak, Jean-Pierre Kinet
May 22, 2020·Molecular and Cellular Biochemistry·Muhammad AfzalKhalil Ahmed
Sep 22, 2020·ELife·Marie E SweetDavid L Stokes
Oct 25, 2020·European Journal of Immunology·Mark KorthalsKlaus-Dieter Fischer
Nov 18, 2020·The Journal of Biological Chemistry·Stephanie ThibodeauJonathan Lytton
Nov 5, 2019·Neuroscience·Vitor S AlvesFernando A Oliveira
Dec 18, 2019·Cell Calcium·Mohamed Tarek Hassan, Jonathan Lytton
Jan 19, 2021·The Journal of Biological Chemistry·Stephanie ThibodeauJonathan Lytton
Apr 4, 2021·International Journal of Molecular Sciences·Tomasz BoczekLudmila Zylinska
Feb 28, 2019·Journal of Chemical Theory and Computation·Matías R MachadoSergio Pantano
Aug 31, 2021·Frontiers in Endocrinology·Veronica CostinitiRodrigo S Lacruz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.

Related Papers

Biochemical and Biophysical Research Communications
Marisa BriniTito Calì
The International Journal of Biochemistry & Cell Biology
Marta GiacomelloErnesto Carafoli
© 2022 Meta ULC. All rights reserved