Regulation of cell cycle progression and apoptosis by the papillomavirus E6 oncogene

Critical Reviews in Eukaryotic Gene Expression
Xueli Fan, Jason J Chen

Abstract

Infection with human papillomaviruses (HPV) is strongly associated with the development of cervical cancer. The HPV E6 gene is essential for the oncogenic potential of HPV. E6 abrogates multiple cell cycle checkpoints and modulates apoptosis. Loss of cell cycle checkpoints contributes to genomic instability, a hallmark of cancer cells. Cancer cells also show reduced propensity for apoptotic cell death. Inactivation of the tumor suppressor p53 by E6 is an important mechanism by which E6 promotes cell growth. The molecular basis for apoptosis modulation by E6 is poorly understood. Although it is expected that inactivation of p53 by E6 should lead to a reduction in cellular apoptosis, numerous studies showed that E6 could in fact sensitize cells to apoptosis. In this article, we present an overview of observations and current understanding of the molecular basis for E6-induced cell proliferation and apoptosis.

Citations

Jun 9, 2006·International Orthopaedics·Francisco GomarFederico Arrizabalaga
Dec 22, 1999·Matrix Biology : Journal of the International Society for Matrix Biology·A LochterM J Bissell
Apr 24, 1999·The Biochemical Journal·N J Boudreau, P L Jones
Feb 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·J U Gutterman
Jul 31, 1998·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C HagiosM J Bissell
Sep 28, 2013·BMC Cell Biology·Kate LawrensonSimon A Gayther
May 29, 2013·Virology·Scott B Vande Pol, Aloysius J Klingelhutz
Oct 8, 2013·Expert Opinion on Therapeutic Targets·Joaquin Manzo-MerinoLawrence Banks
Jul 30, 2014·PLoS Biology·Richard P Halley-StottJohn Gurdon
Jun 13, 2018·Journal of Cellular and Molecular Medicine·Yonghao TianWeifang Zhang

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