Regulation of cell migration by α4 and α9 integrins.

The Biochemical Journal
Willow Hight-Warburton, Maddy Parsons

Abstract

Integrins are heterodimeric transmembrane receptors that play an essential role in enabling cells to sense and bind to extracellular ligands. Activation and clustering of integrins leads to the formation of focal adhesions at the plasma membrane that subsequently initiate signalling pathways to control a broad range of functional endpoints including cell migration, proliferation and survival. The α4 and α9 integrins form a small sub-family of receptors that share some specific ligands and binding partners. Although relatively poorly studied compared with other integrin family members, emerging evidence suggests that despite restricted cell and tissue expression profiles, these integrins play a key role in the regulation of signalling pathways controlling cytoskeletal remodelling and migration in both adherent and non-adherent cell types. This review summarises the known shared and specific roles for α4 and α9 integrins and highlights the importance of these receptors in controlling cell migration within both homeostatic and disease settings.

References

Mar 1, 1995·The Journal of Cell Biology·R AlonT A Springer
Jun 1, 1995·Molecular Biology of the Cell·P D KassnerM E Hemler
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·U GosslarB Holzmann
Apr 27, 2000·The Journal of Biological Chemistry·S Liu, M H Ginsberg
Jun 17, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L HäkkinenH Larjava
Sep 5, 2001·The Journal of Biological Chemistry·J HanM H Ginsberg
May 4, 2002·Annual Review of Biophysics and Biomolecular Structure·Motomu ShimaokaTimothy A Springer
Feb 8, 2003·The Journal of Biological Chemistry·Ramesh M RayLeonard R Johnson
Apr 17, 2003·The Journal of Surgical Research·John E BartschHubert E Appert
May 26, 2004·Biochemical Society Transactions·R Zaidel-BarB Geiger
Apr 25, 2006·Annals of Neurology·Masaaki NiinoAmit Bar-Or
Dec 14, 2006·Journal of Cell Science·Ronen Zaidel-BarBenjamin Geiger
Mar 21, 2007·Nature Cell Biology·Chinten James LimMark H Ginsberg
Aug 3, 2007·Nature Cell Biology·Ronen Zaidel-BarBenjamin Geiger
May 16, 2008·Proceedings of the National Academy of Sciences of the United States of America·Gregory W deHartDean Sheppard
Jul 18, 2008·The Journal of Investigative Dermatology·Purva SinghLivingston Van De Water
Sep 12, 2008·Molecular Biology of the Cell·Chinten J LimMark H Ginsberg
Jan 2, 2009·Journal of Cell Science·Coert MargadantArnoud Sonnenberg

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