Regulation of cellular actin architecture by S100A10

Experimental Cell Research
M Juliane JungChristian Melle

Abstract

Actin structures are involved in several biological processes and the disruption of actin polymerisation induces impaired motility of eukaryotic cells. Different factors are involved in regulation and maintenance of the cytoskeletal actin architecture. Here we show that S100A10 participates in the particular organisation of actin filaments. Down-regulation of S100A10 by specific siRNA triggered a disorganisation of filamentous actin structures without a reduction of the total cellular actin concentration. In contrast, the formation of cytoskeleton structures containing tubulin was unhindered in S100A10 depleted cells. Interestingly, the cellular distribution of annexin A2, an interaction partner of S100A10, was unaffected in S100A10 depleted cells. Cells lacking S100A10 showed an impaired migration activity and were unable to close a scratched wound. Our data provide first insights of S100A10 function as a regulator of the filamentous actin network.

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Citations

Jul 3, 2013·Cellular and Molecular Life Sciences : CMLS·Stephane R GrossPhilip S Rudland
Nov 21, 2012·Hepatitis Monthly·Claudia MaletzkiClaus Kerkhoff
Oct 16, 2019·Pathology International·Yuriko Saiki, Akira Horii
Nov 7, 2012·Molecular and Cellular Biochemistry·Shurovi SayeedTakeshi Senga

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