Regulation of cellular gene expression by interferon-gamma: involvement of multiple pathways

International Journal of Cell Cloning
S L Gupta

Abstract

Interferons (IFNs) classified as type I (IFN-alpha and -beta) and type II (IFN-gamma) interact with different receptors and regulate the expression of a number of genes in common, whereas the expression of certain other genes is regulated differentially by the type I or type II IFNs. Regulation of cellular gene expression by IFN-gamma was studied with the help of two cDNA clones (called C5-4 and C13) isolated in our laboratory and cDNA clones for human leukocyte antigen (HLA) class I (HLA-B) and class II (HLA-DR alpha, -DR beta) genes. The results indicate that IFN-gamma induced the expression of the cognate genes, but in different manners. IFN-gamma induced the transcription of all four genes as determined by nuclear run-on transcription analyses, but the induction of C5-4 genes transcription was inhibited by cycloheximide and anisomycin, indicating that some newly synthesized protein, presumably induced by IFN-gamma, was required for the transcriptional activation of the C5-4 gene. On the contrary, IFN-gamma-induced transcription of HLA class I, class II and C13 genes was unaffected by cycloheximide or anisomycin. However, these inhibitors completely blocked the accumulation of the HLA class II gene transcripts, but not HLA c...Continue Reading

References

Jan 1, 1987·Annual Review of Biochemistry·S PestkaC E Samuel
Dec 1, 1988·Immunology Today·J A Langer, S Pestka
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·L E ReidI M Kerr
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·P V BastaJ P Ting
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·T C DaleG R Stark
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M A BlanarR A Flavell
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·F H Sarkar, S L Gupta
Dec 24, 1981·Nature·A A Branca, C Baglioni
Apr 1, 1985·Immunology Today·G Trinchieri, B Perussia

❮ Previous
Next ❯

Citations

Sep 11, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Mustapha AllamLyne Gagnon
Apr 6, 2006·Journal of Ethnopharmacology·Choi-Lan HaMing-Jiuan Wu
Dec 31, 1997·The Journal of Biological Chemistry·A SicaH A Young
Dec 1, 2001·The Journal of Biological Chemistry·Victoria Y GorbachevaDeborah J Vestal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.