Regulation of ceramide production and apoptosis

Annual Review of Physiology
R N Kolesnick, M Krönke

Abstract

Ceramide is a sphingosine-based lipid signaling molecule that regulates cellular differentiation, proliferation, and apoptosis. The emerging picture suggests that coupling of ceramide to specific signaling cascades is both stimulus and cell-type specific. Ceramide action is determined within the context of other stimuli and by the subcellular topology of its production. Here, we discuss the pathways of ceramide generation and the interaction of ceramide with caspases and other apoptotic signaling cascades.

References

Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S MathiasR N Kolesnick
May 1, 1990·Biochimica Et Biophysica Acta·A H Merrill, D D Jones
Nov 24, 1995·Science·Z XiaM E Greenberg
Nov 10, 1995·The Journal of Biological Chemistry·P Liu, R G Anderson
May 24, 1995·Biochimica Et Biophysica Acta·S J KorsmeyerG P Linette
Jun 1, 1995·Immunology Today·M PushkarevaY A Hannun
May 12, 1995·The Journal of Biological Chemistry·K BernardoK Sandhoff
Aug 1, 1994·The Journal of Experimental Medicine·A Haimovitz-FriedmanR N Kolesnick
May 12, 1994·Nature·J M KyriakisJ R Woodgett
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·W D JarvisS Grant
Jan 1, 1994·The Journal of Cell Biology·J C Reed
Sep 10, 1993·Cell·L A TartagliaD V Goeddel
Mar 19, 1993·Science·L M ObeidY A Hannun
Mar 1, 1996·The Journal of Biological Chemistry·A M ChinnaiyanV M Dixit
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·J ZhangY A Hannun
Jun 11, 1996·Biochimica Et Biophysica Acta·L R BallouR Raghow
Apr 1, 1996·The Journal of Experimental Medicine·N ZamzamiG Kroemer
Jun 14, 1996·Cell·A Fraser, G Evan
Jul 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·A HuwilerJ Pfeilschifter
Apr 1, 1996·Current Opinion in Cell Biology·S SpiegelR Kolesnick

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Citations

Jul 27, 2000·Journal of Cellular Physiology·R N KolesnickA Alonso
Apr 30, 2003·Journal of Biochemical and Molecular Toxicology·Diptendu ChatterjeeSalil K Das
May 9, 2003·Archives of Pharmacal Research·Sejin LimChul Bu Yim
Jul 10, 2007·Archives of Pharmacal Research·Kyoungwon KimChulbu Yim
Jun 26, 2012·Cellular and Molecular Life Sciences : CMLS·Chiara Mencarelli, Pilar Martinez-Martinez
Apr 20, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Philipp A LangFlorian Lang
Dec 21, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Daniela S KempeFlorian Lang
Nov 26, 2009·Cancer Chemotherapy and Pharmacology·Yan LiuPing Xie
Dec 7, 2007·Pflügers Archiv : European journal of physiology·Jan P NicolayFlorian Lang
Mar 30, 2010·Pflügers Archiv : European journal of physiology·Qinghuan XiaoKuai Yu
Sep 2, 2004·Journal of Cancer Research and Clinical Oncology·Aruna S Jaiswal, Satya Narayan
Nov 9, 2010·International Journal of Clinical Oncology·Kazunori FujiwaraToshiro Okazaki
Apr 22, 2005·Apoptosis : an International Journal on Programmed Cell Death·S W WangV Duronio
Feb 13, 2007·Apoptosis : an International Journal on Programmed Cell Death·Albert MoralesJosé C Fernandez-Checa
Jul 17, 2007·Journal of Inherited Metabolic Disease·E H Schuchman
Sep 17, 2005·Journal of Bioenergetics and Biomembranes·Leah J Siskind
Sep 26, 2013·Pharmaceutical Research·Peng ZouDuxin Sun
Jan 20, 2004·Biochimica Et Biophysica Acta·Yusuke NakadeTakashi Murate
Mar 5, 2005·The Journal of Laboratory and Clinical Medicine·Nozomi IwanagaKatsumi Eguchi
Aug 21, 2003·Analytical Biochemistry·Meryem BektasSarah Spiegel
Jun 8, 2002·Biochemical and Biophysical Research Communications·Yukihiro AkaoYoshinori Nozawa
Apr 25, 2003·Biochemical and Biophysical Research Communications·Young-Mi HamSeung-Ki Lee
May 6, 2003·Biochemical and Biophysical Research Communications·José C Fernández-Checa
Sep 23, 2000·Chemistry and Physics of Lipids·A Nilsson, R D Duan
Sep 23, 2000·Chemistry and Physics of Lipids·M Krönke
Jun 5, 2002·European Journal of Pharmacology·Keith W CrawfordWayne D Bowen
Aug 14, 2003·Experimental Cell Research·Vladislav DolgachevDuska Separovic
Aug 26, 1999·Life Sciences·M Guzmán, C Sánchez
Nov 15, 2003·Neuropharmacology·Mee-Sook Song, Elena I Posse de Chaves
Apr 28, 2001·Prostaglandins & Other Lipid Mediators·A Olivera, S Spiegel
Jan 25, 2003·Cell Calcium·K W Young, S R Nahorski
May 9, 2000·Progress in Lipid Research·N AugéT Levade
Feb 13, 2001·Trends in Pharmacological Sciences·M GuzmánC Sánchez
Apr 3, 2001·Journal of Hepatology·L M FragoI Varela-Nieto
Apr 20, 2001·Neurochemistry International·B MontiA Contestabile
Jan 17, 2002·Neurochemistry International·Laura ColombaioniMercedes Garcia-Gil

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Methods Mentioned

BETA
environmental stresses
ICE
acylation
deacylation
RIP
two-hybrid
co-immunoprecipitation

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