Regulation of cerebral arterial BKCa channels by angiotensin II signaling in adult offspring exposed to prenatal high sucrose diets

Bioscience Reports
Xiuxia GuZhice Xu

Abstract

Prenatal insults have been shown to affect vascular functions, leading to increased risks of cardiovascular diseases in offspring. The present study determined whether high sucrose (HS) intake in pregnancy affected central vascular functions in middle cerebral artery (MCA) of offspring. Sprague-Dawley rats were fed a standard food and tap water with normal or high (20%) sucrose content during pregnancy. Offspring were maintained with normal diets and tap water. Central vascular functions and related ion channels were assessed in male offspring at 5 months old. Compared with the control, angiotensin II (AII)-induced vasoconstrictions were significantly higher in the MCA of the offspring exposed to prenatal HS. In the MCA, large conductance Ca2+-activated K+channels (BKCa) currents were decreased with a reduction of opening frequency, sensitivity to intracellular Ca2+/membrane voltage, and BKβ1 expression. mRNA levels of AT1α and AT2, as well as AT1/AT2 ratio, were significantly increased in the MCA of offspring following exposure to prenatal HS diets. The data suggested that prenatal HS diets could alter microvascular activities in the MCA, probably via changes of BKCa channels in the brain.

References

Jan 21, 2000·Hypertension·W F Jackson
Jul 17, 2001·The Journal of Biological Chemistry·G M DickK M Sanders
Apr 27, 2004·Journal of Pharmacological Sciences·Yoshio TanakaLigia Toro
Aug 22, 2006·Journal of Molecular and Cellular Cardiology·Yasunobu HayabuchiShoji Kagami
Jan 11, 2007·American Journal of Physiology. Endocrinology and Metabolism·Lucie SedováDrahomíra Krenová
Jun 17, 2008·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Eun A KoWon Sun Park
Feb 4, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Staci D Bilbo, Verne Tsang
Feb 23, 2010·Drug Discovery Today·Lijun ShiLubo Zhang
May 4, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Lauren HowittTimothy V Murphy
Sep 27, 2012·Clinical Endocrinology·James R O'Reilly, Rebecca M Reynolds
Sep 28, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Shigang LiZhice Xu
Sep 7, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Joanna L MergecheEric J Heyer
Mar 13, 2014·Investigative Ophthalmology & Visual Science·Maurice NeedhamJ Graham McGeown
May 9, 2014·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Chonglong WuZhice Xu
Jul 8, 2014·The Journal of Nutritional Biochemistry·Hanzhe KuangZhice Xu
Apr 29, 2015·Hormones and Behavior·Elinor L SullivanJeanette C Valleau
Sep 6, 2015·The European Respiratory Journal·Olivier BoucheratSébastien Bonnet

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