Regulation of cGMP-induced relaxation and cGMP-dependent protein kinase in rat myometrium during pregnancy

The American Journal of Physiology
R A Word, T L Cornwell

Abstract

Increases in guanosine 3',5'-cyclic monophosphate (cGMP) induced by nitric oxide (NO), nitrovasodilators, and atrial peptides correlate with relaxation of vascular smooth muscle. Relaxation of myometrial smooth muscle by increases in cGMP, however, has required unusually high concentrations of the cyclic nucleotide. We tested the hypothesis that the sensitivity of myometrium to relaxation by cGMP is increased during pregnancy. Aortic smooth muscle was more sensitive to relaxation by cGMP than myometrial tissues, and, contrary to our hypothesis, myometrium from pregnant rats was least sensitive. Although levels of cGMP were elevated after treatment with the NO donor, S-nitroso-N-acetylpenicillamine, relaxation of myometrial tissues obtained from pregnant rats occurred only at extraordinarily high concentrations. The levels of cGMP-dependent protein kinase (PKG) were significantly decreased in myometrium from pregnant rats compared with myometrium from nonpregnant cycling animals or aortic smooth muscle. Administration of estradiol to ovariectomized rats increased myometrial PKG expression, and progesterone antagonized this response. We conclude that 1) myometrial tissues from pregnant rats are not sensitive to relaxation by cGMP...Continue Reading

References

Aug 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·T M LincolnJ D Corbin
Apr 1, 1991·The American Journal of Physiology·R A WordJ T Stull
Oct 1, 1991·American Journal of Obstetrics and Gynecology·R A AhokasB M Sibai
Jan 1, 1989·Pharmacology & Therapeutics·T M Lincoln
Jun 1, 1995·European Journal of Obstetrics, Gynecology, and Reproductive Biology·H Izumi, R E Garfield
Jul 15, 1993·Biochemical and Biophysical Research Communications·E S NatuzziR K Riemer
Nov 1, 1993·American Journal of Obstetrics and Gynecology·S M SladekJ M Roberts
Nov 1, 1994·American Journal of Obstetrics and Gynecology·A L DiketM J Miller
Nov 1, 1993·American Journal of Obstetrics and Gynecology·H IzumiR E Garfield
Jan 1, 1996·Annual Review of Physiology·J T FinnK W Yau
Feb 1, 1997·British Journal of Obstetrics and Gynaecology·G D Jones, L Poston
Jul 1, 1997·Journal of Vascular Research·N J BoerthT M Lincoln

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Citations

Jul 24, 2010·The Journal of Pharmacology and Experimental Therapeutics·Iain L O BuxtonStephen D Tichenor
Feb 10, 1999·The American Journal of Physiology·V P FominR A Word
Jul 27, 2000·Journal of Cellular Physiology·J A CarvajalC P Weiner
Aug 4, 2001·The Journal of Biological Chemistry·J J KhatriS A Fisher
Feb 14, 2003·American Journal of Physiology. Cell Physiology·Trudy L CornwellRakesh P Patel
Nov 18, 2000·American Journal of Physiology. Cell Physiology·X B ZhouM Korth
Apr 8, 2011·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S S HassanUNKNOWN PREGNANT Trial
May 28, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Shoichi MagawaTomoaki Ikeda
Dec 22, 1999·The Journal of Physiology·S R BartlettR Poston
Oct 24, 2001·Biology of Reproduction·D MinjarezR A Word
Apr 21, 2012·Phytotherapy Research : PTR·Yun Hwan KangHeung Mook Shin
Jan 28, 2003·American Journal of Obstetrics and Gynecology·Jorge A CarvajalCarl P Weiner

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