PMID: 8611014Feb 13, 1996Paper

Regulation of chemokine gene expression by contact hypersensitivity and by oral tolerance

Annals of the New York Academy of Sciences
Y S YuanJ Battisto

Abstract

In mice with hapten-induced CH, T cells of the CD4+ and CD8+ phenotypes activated the gene for JE, whereas CD8+ T cells alone caused activation of the gene for IP-10. In animals tolerized by feeding either TNCB or OX, hapten-induced expression of IP-10 but not JE mRNA was lost. The down-regulation of IP-10 gene activation was adoptively transferred from tolerized mice to naive mice by CD4+ splenic T cells. These findings reflect the differential roles of individual T-cell subsets in both enhancing and diminishing chemokine gene expression in contact hypersensitivity reactions.

References

Jan 1, 1991·Annual Review of Immunology·J J OppenheimK Matsushima
Jun 1, 1993·Bio/technology·D Michiel
Apr 1, 1994·Journal of Leukocyte Biology·S GautamT A Hamilton
Sep 1, 1993·The Journal of Experimental Medicine·A D Luster, P Leder

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Citations

Feb 21, 2004·International Immunopharmacology·Gaku MitsuiMasatoshi Kato
Jun 28, 2011·The American Journal of Pathology·Yoshihiro YamamotoTakahiro Satoh
Mar 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jennifer H DufourAndrew D Luster
Dec 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·D E FaunceJ Stein-Streilein

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