PMID: 6673071Nov 1, 1983Paper

Regulation of cholesterol synthesis in jejunal absorptive cells of the rat

Scandinavian Journal of Gastroenterology
T E StrandbergT A Miettinen

Abstract

Cholesterol metabolism was studied in jejunal mucosa of the rat with special emphasis on cholesterol synthesis of villous cells, the site of intestinal lipid absorption. The type of diet and nutritional state clearly affected the cholesterologenesis of villous cells. Consequently, the incorporation of 14C-acetate into nonsaponifiable lipids (NSL; includes squalene and sterols) decreased in the following order of magnitude: 1) fat-free diet supplemented with safflower oil (FFD-SO), 2) FFD alone, 3) standard rat chow, 4) 1% cholesterol in FFD-S(, 5) total fast. Both the cholesterol feeding and the fast increased the total cholesterol concentrations in the villous cells, but the concentrations were unaffected by the other diets. In rats fed FFD-SO diet the cholesterol synthesis was significantly higher in the villous than in the crypt cells, although the cellular cholesterol concentrations were similar. The hepatic cholesterol synthesis from 14C-acetate was low in rats fed FFD-SO as compared with chow diet, whereas the incorporation of 14C-acetate into hepatic fatty acids and the incorporation of 3H-mevalonate into NSL were not affected by the diet. 5% cholestyramine had no significant effect on the cholesterol synthesis or choles...Continue Reading

References

Jan 16, 1976·Science·M S Brown, J L Goldstein
Oct 26, 1979·Biochimica Et Biophysica Acta·W Bochenek, J B Rodgers
Feb 1, 1968·The Journal of Clinical Investigation·J M Dietschy
Apr 1, 1971·The Journal of Clinical Investigation·J M Dietschy, W G Gamel
Aug 1, 1965·The Journal of Clinical Investigation·J M Dietschy, M D Siperstein
May 13, 1982·Biochimica Et Biophysica Acta·D J McNamaraK D Edwards
Jan 1, 1981·Scandinavian Journal of Gastroenterology·T E StrandbergT A Miettinen
Dec 1, 1962·The American Journal of Physiology·J D Wilson

Citations

Jan 1, 1988·General Pharmacology·T E Strandberg, R S Tilvis
Jun 1, 1993·Lipids·H M StormS Norton
Aug 6, 2005·The Journal of Veterinary Medical Science·Masaji SaitohMasakazu Nishimura

Related Concepts

Epicholesterol
Cholesterol, Dietary
MK-135
Fasting
Intestinal Absorption
Structure of Intestinal Gland
Jejunum
Microvilli
August Rats

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