Regulation of Chylomicron Secretion: Focus on Post-Assembly Mechanisms

Cellular and Molecular Gastroenterology and Hepatology
Changting XiaoGary F Lewis

Abstract

Rapid and efficient digestion and absorption of dietary triglycerides and other lipids by the intestine, the packaging of those lipids into lipoprotein chylomicron (CM) particles, and their secretion via the lymphatic duct into the blood circulation are essential in maintaining whole-body lipid and energy homeostasis. Biosynthesis and assembly of CMs in enterocytes is a complex multistep process that is subject to regulation by intracellular signaling pathways as well as by hormones, nutrients, and neural factors extrinsic to the enterocyte. Dysregulation of this process has implications for health and disease, contributing to dyslipidemia and a potentially increased risk of atherosclerotic cardiovascular disease. There is increasing recognition that, besides intracellular regulation of CM assembly and secretion, regulation of postassembly pathways also plays important roles in CM secretion. This review examines recent advances in our understanding of the regulation of CM secretion in relation to mobilization of intestinal lipid stores, drawing particular attention to post-assembly regulatory mechanisms, including intracellular trafficking of triglycerides in enterocytes, CM mobilization from the lamina propria, and regulated t...Continue Reading

Citations

Jul 12, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Priska StahelGary F Lewis
Sep 11, 2019·The Journal of Nutrition·Heather A McCauley
Jul 31, 2019·Current Opinion in Lipidology·Krista HokkanenSeppo Ylä-Herttuala
Apr 12, 2020·Experimental Biology and Medicine·Kenneth Raj, Steve Horvath
Aug 1, 2020·Frontiers in Physiology·Chunmin C Lo, Karen T Coschigano
Feb 18, 2020·Frontiers in Physiology·Changting XiaoGary F Lewis
Apr 2, 2020·Frontiers in Endocrinology·Priska StahelGary F Lewis
Jun 26, 2020·Colloids and Surfaces. B, Biointerfaces·Ruojie ZhangDavid Julian McClements
Oct 8, 2020·Molecular & Cellular Proteomics : MCP·Matthias SchittmayerRuth Birner-Gruenberger
Jan 28, 2021·Diabetes, Obesity & Metabolism·Marja-Riitta TaskinenJan Borén
Jan 17, 2021·Molecular & Cellular Proteomics : MCP·Matthias SchittmayerRuth Birner-Gruenberger
Mar 7, 2021·Nutrients·Zeyad KhalilHarbans Sharma
May 11, 2021·Clínica e investigación en arteriosclerosis : publicación oficial de la Sociedad Española de Arteriosclerosis·José T Real, Juan F Ascaso
Jul 21, 2021·Annual Review of Nutrition·Alyssa S ZembroskiKimberly K Buhman
Nov 9, 2021·Mass Spectrometry Reviews·Erica GianazzaCristina Banfi

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Methods Mentioned

BETA
lipidation
glycosylation
biopsy

Software Mentioned

vSNARE

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