Jul 19, 2013

Regulation of circadian clocks by redox homeostasis

The Journal of Biological Chemistry
Alessandra Stangherlin, Akhilesh B Reddy

Abstract

Living organisms possess biological clocks that resonate with environmental cycles in light, temperature, and food availability. Recently, circadian oscillations in the redox state of peroxiredoxin have been described as an additional non-transcriptional timekeeping mechanism. Of note, this redox cycle is conserved in both prokaryotes and eukaryotes. How the classical "transcription-translation feedback loop" model and this redox oscillation are related is still poorly understood. In this minireview, we describe the most recent evidence pointing to cross-talk between the circadian clock and the redox status of the cell.

Mentioned in this Paper

Thioredoxin Reductase (NADPH)
Dioxygen
Cross-talk
Thioredoxin-2
Perhydrol
Circadian Clocks
Transcription, Genetic
Alkyl Hydroperoxide Reductase D
Gene Expression Regulation, Enzymologic
PRDX1

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