Jan 1, 1975

Regulation of citrate synthase activity of Saccharomyces cerevisiae

Antonie van Leeuwenhoek
J S Coleman, J K Bhattacharjee


Citrate synthase activity of Saccharomyces cerevisiae was determined by a radioactive assay procedure and the reaction product, 14C-citric acid, was identified by chromatographic techniques. ATP, d-ATP, GTP and NADH were most inhibitory to the citrate synthase invitro. The activity was inhibited to a lesser extent by ADP, UTP, and NADP whereas, AMP and CTP were much less inhibitory. NADH, like NAD, glutamic acid, glutamine, arginine, ornithine, proline, aspartic acid and alpha-ketoglutarate exhibited no inhibition. These results have been discussed in the light of the role of citrate synthase for the energy metabolism and glutamic acid biosynthesis.

  • References15
  • Citations5


  • References15
  • Citations5

Mentioned in this Paper

Saccharomyces cerevisiae allergenic extract
Glutamate Biosynthetic Process
Citricum acidum, citric acid, homeopathic preparation
Energy Metabolism
Alpha Ketoglutarate
Citrate (si)-Synthase

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