PMID: 8595132Nov 1, 1995Paper

Regulation of classical HLA class I genes in human choriocarcinoma cells by nuclear proteins binding to MHC class I regulatory elements

American Journal of Reproductive Immunology : AJRI
A WakimotoO Tanizawa

Abstract

The regulation of classical HLA class I genes in choriocarcinoma have been reported. We determined whether four choriocarcinoma cell lines expressed classical HLA class I or HLA-G by a reverse transcription-polymerase chain reaction (RT-PCR) and studied the regulatory mechanism of classical class I using a gel mobility shift assay. NUC1 and SCH expressed classical class I but not HLA-G. GCH1 and Jar did neither. Nuclear protein binding to the class I regulatory element (CRE) was detected in NUC1 and SCH. Interferon-gamma augmented both classical class I expression and the DNA-protein complex in NUC1. The DNA-protein complex was not observed in GCH1, and Jar showed a CRE-binding protein with different electrophoretic mobility and binding affinity from that of SCH and NUC1. The CRE is one of the regulatory elements of classical HLA class I genes in choriocarcinoma cells.

References

Dec 1, 1976·Transplantation·P N GoodfellowM J Crumpton
Jan 1, 1990·Immunologic Research·H Heinrichs, H T Orr
May 1, 1990·American Journal of Reproductive Immunology : AJRI·K OhashiO Tanizawa
Apr 13, 1990·Science·S KovatsR DeMars
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R SrivastavaS M Weissman
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J MiyazakiK Ozato
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·D E GeraghtyH T Orr
Oct 1, 1980·Gynecologic Oncology·N P VeridianoM L Tancer

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Citations

Dec 16, 1998·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·T KimuraF Saji

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