PMID: 8943893Dec 1, 1996Paper

Regulation of clinical chemoresistance by bcl-2 and bax oncoproteins in B-cell chronic lymphocytic leukaemia

British Journal of Haematology
C PepperT Hoy

Abstract

The bcl-2 gene was first shown to be dysregulated in the majority of follicular lymphomas in which a t(14;18) chromosomal translocation is present, but is also over-expressed in the absence of gene rearrangements in most cases of B-cell chronic lymphocytic leukaemia (B-CLL). The bcl-2 oncoprotein is a regulator of apoptosis and the activity of this protein is opposed by bax, a homologous protein that accelerates the rate of cell death. B-lymphocyte bcl-2 and bax protein levels were found to be significantly altered in B-CLL patients when compared to those of a normal control group. Increased bcl-2/bax ratios were observed in both the treated and untreated patients when compared to those of normal controls. These alterations were particularly pronounced in those treated patients found to be clinically unresponsive to chemotherapy.

Citations

Oct 12, 2000·Hematological Oncology·D P Bentley, C J Pepper
Dec 30, 2004·Cytometry. Part B, Clinical Cytometry·Charles GoolsbyRonald B Gartenhaus
Feb 10, 1999·Medical Oncology·L M Osorio, M Aguilar-Santelises
Apr 29, 1999·International Journal of Radiation Oncology, Biology, Physics·M D LogsdonT J McDonnell
Apr 20, 2004·Critical Reviews in Oncology/hematology·Jan Maxwell NørgaardPeter Hokland
Apr 21, 1998·Critical Reviews in Oncology/hematology·J Jurlander
Aug 7, 2002·Antisense & Nucleic Acid Drug Development·Richard J KlasaStanley R Frankel
May 6, 2004·Journal of the National Cancer Institute·Oksana MoshynskaAnurag Saxena
May 6, 2004·Journal of the National Cancer Institute·Shinichi Kitada, John C Reed
Feb 25, 2000·Current Opinion in Oncology·R Bannerji, J C Byrd
Dec 17, 2008·Hematology·Susan O'Brien
Nov 23, 2006·Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology·F ScamardellaM Brini
Aug 31, 2001·Biochemical and Biophysical Research Communications·K AntokuD E Johnson
Dec 4, 2013·Leukemia & Lymphoma·Shadia ZamanVarsha Gandhi
Aug 26, 1998·Leukemia & Lymphoma·L M OsorioM Aguilar-Santelises
Nov 24, 2007·Expert Opinion on Biological Therapy·Michael BoyiadzisSteven Pavletic
Jul 14, 2010·Best Practice & Research. Clinical Haematology·Erin Hertlein, John C Byrd
Nov 30, 2005·Journal of Internal Medicine·B Fadeel, S Orrenius
May 16, 2013·Cytometry. Part B, Clinical Cytometry·Heba A DegheidyGerald E Marti
Dec 31, 2009·The Journal of Pathology·Ashley HamiltonTessa L Holyoake
Dec 17, 2014·Immunological Reviews·Kristy L Richards, Steven E Suter
Dec 29, 2000·The Tohoku Journal of Experimental Medicine·K OgawaY Maruyama
Aug 8, 1998·The Journal of Surgical Research·K KnowltonB O Anderson
May 9, 2015·Cell Death and Differentiation·A R D Delbridge, A Strasser
Sep 8, 2016·Clinical Lymphoma, Myeloma & Leukemia·Suliman A AlsagabyChris Pepper
Sep 28, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan M O'BrienKanti R Rai

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