Regulation of connexin 36 expression during development.

Neuroscience Letters
Ji-Hoon SongAndrei B Belousov

Abstract

In the mammalian CNS, the expression of neuronal gap junction protein, connexin 36 (Cx36), increases during the first 2 weeks of postnatal development and then decreases during the following 2 weeks. Recently we showed that the developmental increase in Cx36 expression is augmented by chronic (2 weeks) activation of group II metabotropic glutamate receptors (mGluR), prevented by chronic receptor inactivation, and the receptor-dependent increase in Cx36 expression is regulated via transcriptional control of the Cx36 gene activity. We demonstrate here that acute (60 min) activation of group II mGluRs in developing cortical neuronal cultures causes transient increase in Cx36 protein expression with decrease during the following 24h. However, there is no change in Cx36 mRNA expression. In addition, the data indicate that transient increase in Cx36 expression is due to new protein synthesis. The results suggest that, during development, acute activation of group II mGluRs causes up-regulation of Cx36 via post-transcriptional mechanisms. However, if the receptor activation is sustained, transcriptional activation of the Cx36 gene occurs.

References

Apr 12, 2003·Developmental Cell·D Thomas Rutkowski, Randal J Kaufman
Jul 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Krishna M Vattem, Ronald C Wek
Apr 23, 2005·The European Journal of Neuroscience·Lena SmirnovaF Gregory Wulczyn
Nov 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ngan VoSoren Impey
Nov 22, 2005·Nature Neuroscience·Harsha ArumugamAndrei B Belousov
Sep 15, 2007·Journal of Neurophysiology·Juan Carlos de Rivero VaccariAndrei B Belousov
Apr 22, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Won-Mee ParkAndrei B Belousov
Jan 13, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yongfu WangAndrei B Belousov

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Citations

Nov 2, 2013·Journal of Neural Transmission·Andrei B Belousov, Joseph D Fontes
Dec 15, 2012·Trends in Neurosciences·Andrei B Belousov, Joseph D Fontes
Nov 18, 2014·Journal of Neuroscience Research·Yoki NakamuraYoshihiro Nakata
Jan 27, 2017·BMC Cell Biology·Andrei B BelousovChristian C Naus
May 28, 2016·BMC Cell Biology·Sebastian Curti, John O'Brien

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