Regulation of connexin-43, GFAP, and FGF-2 is not accompanied by changes in astroglial coupling in MPTP-lesioned, FGF-2-treated parkinsonian mice

Journal of Neuroscience Research
M RuferK Unsicker

Abstract

Basic fibroblast growth factor (bFGF; FGF-2) has potent trophic effects on developing and toxically impaired midbrain dopaminergic (DAergic) neurons which are crucially affected in Parkinson's disease. The trophic effects of FGF-2 are largely indirect, both in vitro and in vivo, and possibly involve intermediate actions of astrocytes and other glial cells. To further investigate the cellular and molecular mechanisms underlying the restorative actions of FGF-2, and to analyse in more detail the changes within astroglial cells in the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-lesioned striatum, we have studied striatal expression and regulation of connexin-43 (cx43), the principal gap junction protein of astroglial cells, along with the expression of glial fibrillary acidic protein (GFAP), FGF-2, and functional coupling. Our results show an immediate, yet transient increase in cx43 mRNA, and a sustained increase in FGF-2 mRNA, GFAP-positive cells, and cx43-immunoreactive punctata following the MPTP lesion, without any induction of functional coupling between astrocytes and other glial cells as revealed by dye coupling of patched cells. Unilateral administration of FGF-2 in a piece of gelfoam caused a further increase in ...Continue Reading

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Citations

Oct 12, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Nathan M KerrHelen V Danesh-Meyer
Oct 25, 2008·Cell Biology International·Colin R Green, Louise F B Nicholson
Apr 3, 2008·Journal of Neuroscience Research·Damian M CummingsMichael S Levine
Sep 30, 2005·Journal of Neurophysiology·Juan Song, Mark A Tanouye
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Aug 19, 2015·Frontiers in Cellular Neuroscience·Lucile Ben HaimCarole Escartin
Jan 7, 2016·Frontiers in Cellular Neuroscience·Laura Fernández-SánchezNicolás Cuenca
Nov 26, 2015·Journal of Alzheimer's Disease : JAD·Geon-Hwi LeeEun-Kyoung Choi
Jun 22, 2017·Neurochemical Research·Marijke De BockChristian Giaume
Feb 20, 2020·International Journal of Molecular Sciences·Hee-Jun KimEun-Kyoung Choi
Feb 4, 2003·Journal of Neurochemistry·Hardy J RideoutLeonidas Stefanis
Mar 24, 2006·The European Journal of Neuroscience·S ZechelO von Bohlen und Halbach
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Nov 19, 1997·Journal of Neuroscience Research·L M FarkasK Unsicker
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Mar 23, 2004·Biochimica Et Biophysica Acta·Taizen Nakase, Christian C G Naus

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