PMID: 6982646Jan 1, 1982Paper

Regulation of contact allergy in the B cell--deficient mouse

Annals of the New York Academy of Sciences
H C Maguire

Abstract

We have examined the obligate role of B cells in the regulation of allergic contact dermatitis. Our model is ACD in mice made B cell deficient by the chronic administration from birth of a goat antisera to mouse IgM. The following ACD phenomena are well demonstrated in these mice: (1) acquisition and expression of ACD, (2) spontaneous waning of ACD soon after sensitization, (3) immunological tolerance induced by pretreatment with either parenteral hapten or haptenated spleen cells, (4) immunopotentiation by means of either cyclophosphamide or the local administration of a suspension of killed C. parvum (P. acnes), (5) the flare-up of previous test sites following the local administration of parenteral allergen, and (6) acquisition and expression of photo-ACD. We conclude that B cell participation is not required for these ACD phenomena, although an optional or subsidiary function for B regulatory cells is not excluded.

References

Jan 1, 1979·Journal of Immunological Methods·J Gordon
Jan 11, 1976·International Archives of Allergy and Applied Immunology·W P WeidanzH C Maguire
Jan 1, 1975·The Journal of Experimental Medicine·P H Lagrange, G B Mackaness
Oct 11, 1974·Nature·S I KatzJ L Turk
Mar 1, 1974·The Journal of Experimental Medicine·G B MackanessT Ishibashi
Jun 1, 1974·The Journal of Experimental Medicine·P H LagrangeT E Miller
Aug 1, 1973·The Journal of Investigative Dermatology·E D Lowney
Jan 1, 1967·The Journal of Investigative Dermatology·H C Maguire, V L Ettore
Jan 1, 1980·Immunological Reviews·M D CooperA R Lawton
Sep 1, 1982·The Journal of Investigative Dermatology·H C Maguire, K Kaidbey
Jan 1, 1956·Proceedings of the Society for Experimental Biology and Medicine·N KALISS, A A KANDUTSCH
Mar 1, 1946·Proceedings of the Society for Experimental Biology and Medicine·M W CHASE

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Citations

May 1, 2003·Lab Animal·Neil S Lipman, Felix R Homberger

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