Regulation of corpus luteum-function in the bitch

Reproduction in Domestic Animals = Zuchthygiene
B HoffmannP C Papa

Abstract

Functional lifespan of the corpus luteum (CL) in non-pregnant dogs exceeds that of pregnant animals and may last for more than 80 days. Prolactin and LH act luteotropic, however, luteolytic mechanisms are poorly understood. Other than in life stock there is no uterine luteolysine and it was postulated that local paracrine/autocrine mechanisms might play a major role. In following this hypothesis the present investigations have clearly demonstrated that up-regulation of prostaglandin synthesis in the CL as indicated by the expression of cyclo-oxygenase II occurs with its formation and not regression, pointing towards a luteotropic rather than luteolytic action. Throughout dioestrus luteal and other cells of the CL express the oestrogen (ERalpha) and progesterone receptor (PR). While ERalpha expression was not cycle-related, PR concentrations were high in the early and late-luteal phase and a regulatory role of both steroids on CL-function is assumed. As in other species also in the dog the immune system seems to participate in the mechanisms regulating CL-function as an increased presence of lymphocytes within the CL could be detected at the beginning [CD4- CD8-, major histocompatibility complex (MHC)II-antigen expressing cells]...Continue Reading

References

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Citations

Nov 1, 2012·Reproductive Biology and Endocrinology : RB&E·Marta J SiemieniuchMariusz P Kowalewski
Jan 1, 2010·Polish Journal of Veterinary Sciences·M J SiemieniuchK Okuda
Nov 26, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Mariusz Pawel KowalewskiBernd Hoffmann
Jan 15, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·Mariusz P KowalewskiIris Reichler
Oct 22, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·Paula de Carvalho PapaMariusz Pawel Kowalewski
Jun 12, 2016·Reproductive Biology·Ewelina Jursza-Piotrowska, Marta J Siemieniuch
Nov 21, 2008·Animal Reproduction Science·Lieta MarinelliGianfranco Gabai
Jun 17, 2008·Theriogenology·K Verstegen-Onclin, J Verstegen
Feb 19, 2008·Animal Reproduction Science·Mariusz Pawel KowalewskiBernd Hoffmann
Sep 17, 2009·Reproduction in Domestic Animals = Zuchthygiene·P W Concannon
Sep 17, 2009·Reproduction in Domestic Animals = Zuchthygiene·N MartinA Einspanier
Jan 4, 2013·Reproduction in Domestic Animals = Zuchthygiene·M P Kowalewski
Feb 22, 2011·Reproduction in Domestic Animals = Zuchthygiene·P C Papa, B Hoffmann
Sep 19, 2006·The Journal of Steroid Biochemistry and Molecular Biology·M P KowalewskiB Hoffmann
Aug 5, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·Aykut GramMariusz P Kowalewski
Nov 3, 2016·The Journal of Endocrinology·Liza Margareth Medeiros de Carvalho SousaPaula de Carvalho Papa
Jul 24, 2010·Toxicologic Pathology·Sundeep A ChandraRick R Adler
Jan 16, 2007·Molecular Reproduction and Development·Susan A PowellAlfred R Menino
Aug 17, 2017·Anais Da Academia Brasileira De Ciências·Vanessa S A GosslerInes C Giometti
Mar 28, 2021·General and Comparative Endocrinology·Ana Paula Mattoso Miskulin CardosoPaula de Carvalho Papa

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