PMID: 20632967Jul 17, 2010Paper

Regulation of corticostriatal synaptic plasticity by G protein-coupled receptors

CNS & Neurological Disorders Drug Targets
R López de Maturana, R Sánchez-Pernaute

Abstract

Dopamine modulation of excitatory neurotransmission is critical in the control of movement, emotion and reward. In the striatum, medium size spiny neurons (MSNs) are responsible for the integration of cortical and thalamic information that flows through parallel, partly overlapping, loops and determines adequate experience-dependent responses. Dopamine acts on MSNs through two sets of G protein-coupled receptors (GPCRs), the D1-like and D2-like receptors, which can have opposing or synergistic downstream effects. Notably, these two types of striatal dopamine receptors are segregated into the striatonigral (direct) and striatopallidal (indirect) projecting neurons. Thus, dopamine receptor expression determines the morphological and functional neuronal phenotype of MSNs. Moreover, dopamine regulates glutamatergic corticostriatal transmission, critically controlling the induction of long-term potentiation and long-term depression at these synapses, regulating striatal synaptic plasticity. In addition to dopamine receptors, the induction and expression of plasticity mechanisms is regulated by other GPCRs, most importantly adenosine A₂(A) receptors, metabotropic glutamate mGluR5 receptors and endocannabinoid CB1 receptors. This revi...Continue Reading

Citations

Jan 24, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Megan L FitzgeraldVirginia M Pickel
Dec 25, 2010·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ariel F MartinezMauricio Arcos-Burgos
Apr 11, 2012·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Zia ChoudhryRidha Joober
Jul 4, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Myles R McCraryShan P Yu
Mar 11, 2016·Physiological Reviews·Martin Korte, Dietmar Schmitz
Jan 8, 2021·The Journal of Biological Chemistry·Katherine E SquiresJohn R Hepler

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