PMID: 11337083May 5, 2001Paper

Regulation of corticotropin-releasing hormone in vitro

Peptides
M PisarskaJ W Kasckow

Abstract

Studies examining regulation of corticotropin-releasing hormone (CRH) in vitro have been used to validate findings obtained in vivo and more importantly have been used as model systems to better understand signalling mechanisms responsible for the expression of the CRH gene and peptide. Most in vitro studies examining CRH have utilized hypothalamic tissue while a few have focused on the amygdala. Furthermore, clonal cell lines have also been utilized as models of central nervous system CRH neurons. Stimuli that have been implicated in regulating hypothalamic CRH in vitro include protein kinase A (PKA) and protein kinase C (PKC) activators, glucocorticoids, biogenic amines, cytokines and the gaseous neurotransmitters. CRH levels in the amygdala in vitro are affected by some of the same stimuli that regulate hypothalamic CRH; however there is evidence supporting differential regulation of CRH in these two brain regions by some of the same stimuli. Only a few studies in aggregate have investigated the signal transduction mechanisms responsible for CRH expression. These mechanistic studies have focused on PKA- and glucocorticoid-mediated changes in CRH expression. Clearly much more investigative work in better understanding CRH reg...Continue Reading

References

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Citations

Feb 18, 2006·PLoS Computational Biology·Yang ZhangJeffrey Skolnick
Jun 15, 2011·Molecular and Cellular Endocrinology·Qing-Yuan MengJiang-Ning Zhou
Jan 1, 2008·Gene Regulation and Systems Biology·Masanori Yoshida
Feb 18, 2006·Biochemical and Biophysical Research Communications·Eduard MurániKlaus Wimmers
Mar 27, 2007·General and Comparative Endocrinology·Meng Yao, Robert J Denver

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