Regulation of cyclin D-dependent kinase activity in rat liver regeneration

Biochemical and Biophysical Research Communications
A KatoF Matsuzaki

Abstract

The regulation of cyclin D-dependent kinase activity in tissue regeneration in vivo has not been fully described. In young adult rat liver after 70% partial hepatectomy, the association of cyclin D1 with cdk4 was significantly promoted during G1 phase and was maximal at 18 hr, corresponding mainly to late G1. Cyclin D1-dependent kinase activity also strongly increased during G1 phase. The timing of the induction of cyclin D1 / cdk4 complex assembly correlated well with that of cyclin D1-dependent kinase activity. At 18 hr after partial hepatectomy, the amounts of CDK inhibitors p21(CIP1) and p27(KIP1) were also maximal, while only one-tenth of p21(CIP1) and of p27(KIP1) was associated with cyclin D1. These findings suggest that cyclin D1, cdk4 and their association act as promoting factors, and that both p21(CIP1) and p27(KIP1) may have physiological functions as adaptor proteins in additions to their roles as CDK inhibitors in rat liver regeneration.

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Citations

Dec 18, 2007·Oncogene·N A OlshavskyK E Knudsen
Jul 29, 2005·Journal of Gastroenterology and Hepatology·Akira KatoYukio Yoshida
Apr 4, 2008·International Journal of Radiation Biology·Sarah KoenigHans Christiansen
Aug 13, 2009·International Journal of Cancer. Journal International Du Cancer·Isidora RanchalJordi Muntané
Apr 6, 2005·Biochemical and Biophysical Research Communications·Joan M Boylan, Philip A Gruppuso
Jan 12, 2002·Journal of Cellular Biochemistry·Itsuki AjiokaYoshifumi Watanabe
Aug 7, 2003·The Journal of Biological Chemistry·Hagir B SulimanClaude A Piantadosi
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Mar 25, 2005·Journal of Neuroscience Research·Rashmi BansalPatrizia Casaccia-Bonnefil
Jan 5, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jose M MatoMatias A Avila
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Mar 21, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Gennady P IlyinChristiane Guguen-Guillouzo

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