Regulation of cyclooxygenase expression in the kidney by dietary salt intake

The American Journal of Physiology
T YangJ P Briggs

Abstract

The present studies were undertaken to determine the effect of dietary salt intake on the renal expression of cyclooxygenase-1 (COX-1) and -2 COX-2). Protein levels were assessed by Western blotting, and mRNA expression was assessed by reverse transcription-polymerase chain reaction (RT-PCR) on cDNA prepared from kidney regions, dissected nephron segments, and cultured renal cells. Both isoforms were expressed at high levels in inner medulla (IM), with low levels detected in outer medulla and cortex. COX-1 mRNA was present in the glomerulus and all along the collecting duct, whereas COX-2 mRNA was restricted to the macula densa-containing segment (MD), cortical thick ascending limb (CTAL), and, at significantly lower levels, in the inner medullary collecting duct. Both isoforms were highly expressed at high levels in cultured medullary interstitial cells and at lower levels in primary mesangial cells and collecting duct cell lines. Maintaining rats on a low- or high-NaCl diet for 1 wk did not affect expression of COX-1. In IM of rats treated with a high-salt diet, COX-2 mRNA increased 4.5-fold, and protein levels increased 9.5-fold. In contrast, cortical COX-2 mRNA levels decreased 2.9-fold in rats on a high-salt diet and incre...Continue Reading

References

Feb 1, 1977·Proceedings of the Society for Experimental Biology and Medicine·M L Kauker
Jun 1, 1977·The Journal of Clinical Investigation·J B Stokes, J P Kokko
Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M K O'BanionD A Young
Jun 1, 1991·Kidney International·B A StoosG Fejes-Tóth
Jul 1, 1987·The American Journal of Physiology·D SchlondorffJ A Satriano
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D L DeWitt, W L Smith
Feb 1, 1985·Journal of Hypertension·E E Muirhead, J A Pitcock
Mar 1, 1986·Proceedings of the Society for Experimental Biology and Medicine·S M WeismanE D Vaughan
Feb 1, 1973·The Journal of Clinical Investigation·T Berl, R W Schrier
Dec 1, 1994·The Journal of Clinical Investigation·R C HarrisM D Breyer
Dec 1, 1993·Archives of Biochemistry and Biophysics·L FengD Hwang
Mar 15, 1993·Annals of the New York Academy of Sciences·O Iimura, K Shimamoto
Nov 3, 1995·Cell·D DeWitt, W L Smith
Jan 5, 1996·Biochimica Et Biophysica Acta·H R Herschman
Mar 1, 1996·Hypertension·D L Mattson, D J Higgins

❮ Previous
Next ❯

Citations

Jan 3, 2001·American Journal of Physiology. Renal Physiology·B MannA Kurtz
Feb 22, 2001·American Journal of Physiology. Renal Physiology·H F ChengR C Harris
Jul 10, 2001·American Journal of Physiology. Cell Physiology·R S OstromP A Insel
Mar 7, 2002·American Journal of Physiology. Renal Physiology·José HernándezBruno Escalante
Nov 21, 2002·American Journal of Physiology. Renal Physiology·Hayo CastropArmin Kurtz
Dec 17, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·David L Mattson
Mar 22, 2003·Acta Physiologica Scandinavica·R LópezF J Salazar
Sep 29, 2005·American Journal of Physiology. Renal Physiology·Wenling YeTianxin Yang
Oct 20, 2005·American Journal of Physiology. Renal Physiology·Lori Warford-WoolgarHarold M Aukema
Jul 18, 2008·American Journal of Physiology. Renal Physiology·Jian ChenChuan-Ming Hao
Oct 8, 2008·Pflügers Archiv : European journal of physiology·Wen-Hui Wang, Gerhard Giebisch
Mar 26, 2010·American Journal of Physiology. Renal Physiology·Zhanjun JiaTianxin Yang
Sep 10, 2010·American Journal of Physiology. Renal Physiology·F Javier Salazar, María T Llinas
May 25, 2012·American Journal of Physiology. Renal Physiology·Carlos P VioNicholas R Ferreri
Nov 15, 2013·American Journal of Physiology. Renal Physiology·Yu LiuRajeev Rohatgi
Mar 22, 2014·American Journal of Physiology. Renal Physiology·Ying LiuTianxin Yang
Dec 17, 2015·American Journal of Physiology. Renal Physiology·Line NilssonRikke Nørregaard
Dec 18, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ulla C KoppLori A Smith
Dec 20, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Harold M AukemaMalcolm R Ogborn
Jan 3, 2001·American Journal of Physiology. Renal Physiology·Z AbassiJ Winaver
Sep 23, 2003·The Journal of Urology·Valeria SolariPrem Puri
Nov 7, 2002·American Journal of Physiology. Renal Physiology·Monica K ChengMairead A Carroll
Dec 29, 2005·American Journal of Physiology. Renal Physiology·Huda Ismail AbdullahNicholas R Ferreri
Dec 29, 2005·American Journal of Physiology. Renal Physiology·Hui-Fang ChengRaymond C Harris
Jan 8, 2005·American Journal of Physiology. Renal Physiology·Wesley MartusWilliam H Beierwaltes
May 29, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ulla C KoppTomas Hökfelt
Jul 30, 2010·American Journal of Physiology. Renal Physiology·Torrance GreenL Gabriel Navar
Apr 16, 2010·Physiological Reviews·Hayo CastropCharlotte Wagner
Mar 29, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mette StæhrBoye L Jensen
May 10, 2013·American Journal of Physiology. Renal Physiology·E I Boesen
Aug 22, 2014·American Journal of Physiology. Renal Physiology·Alexis A GonzalezMinolfa C Prieto
Oct 31, 2014·American Journal of Physiology. Renal Physiology·Allen W CowleyNadezhda N Zheleznova
Jul 29, 2016·American Journal of Physiology. Renal Physiology·Shoujin HaoNicholas R Ferreri
Sep 5, 2019·International Journal of Molecular Sciences·Shanzana KhanJaye P F Chin-Dusting
Jun 7, 2019·The Journal of Toxicological Sciences·Zaher A Radi, K Nasir Khan
Nov 30, 2000·American Journal of Physiology. Renal Physiology·D AndreasenO Skøtt
May 16, 2001·American Journal of Physiology. Renal Physiology·B L JensenO Skøtt
Jul 15, 2000·American Journal of Physiology. Renal Physiology·H F ChengR C Harris
Jul 10, 2003·American Journal of Physiology. Renal Physiology·Ming-Zhi ZhangRaymond C Harris
Jun 8, 2004·American Journal of Physiology. Renal Physiology·Frank SchwedaArmin Kurtz
Jun 16, 2001·American Journal of Physiology. Renal Physiology·R C Harris, M D Breyer
Jun 27, 2008·American Journal of Physiology. Renal Physiology·Yuling ChiVictor L Schuster
May 16, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ulla C KoppLori A Smith
Jul 3, 2009·American Journal of Physiology. Cell Physiology·D Flores-BenitezR G Contreras

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.