PMID: 2121542Oct 29, 1990Paper

Regulation of cytochrome P-450 CYPIA1 gene expression and proto-oncogene expression by growth factors in primary hepatocytes

FEBS Letters
M W HöhneH Taniguchi

Abstract

The effect of growth factors on the cytochrome P-450 (CYPIA1) gene expression was studied in primary mouse hepatocytes. Of the three growth factors used, i.e. epidermal growth factor (EGF), transforming growth factor alpha (TGF alpha) and insulin, only EGF or TGF alpha completely blocked CYPIA1 expression in the presence of the CYPIA1 inducer 3-methylcholanthrene (3-MC). This repression was not linked to cell cycle progression of the hepatocyte because insulin was active to induce 'early immediate genes' and DNA replication as well as EGF/TGF alpha but failed to suppress CYPIA1 expression. A specific EGF/TGF alpha receptor-mediated function may repress CYPIA1 gene expression and contribute to the acquisition of a xenobiotic drug resistance phenotype.

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Citations

Jun 1, 1994·Toxicology in Vitro : an International Journal Published in Association with BIBRA·P Skett
Aug 1, 1999·Toxicology in Vitro : an International Journal Published in Association with BIBRA·K De SmetV Rogiers
Nov 5, 2015·Chemical Research in Toxicology·Afshin Mohammadi-BardboriAgneta Rannug
Jan 24, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Satoru KakizakiMasatomo Mori
Feb 24, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Stephan HailfingerMichael Schwarz
May 30, 2001·Biochemical Pharmacology·A F HederH Desel
Jul 31, 1991·Biochemical and Biophysical Research Communications·A KumatoriA Ichihara

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