Regulation of cytoskeletal dynamics by actin-monomer-binding proteins

Trends in Cell Biology
V PaavilainenP Lappalainen

Abstract

The actin cytoskeleton is a vital component of several key cellular and developmental processes in eukaryotes. Many proteins that interact with filamentous and/or monomeric actin regulate the structure and dynamics of the actin cytoskeleton. Actin-filament-binding proteins control the nucleation, assembly, disassembly and crosslinking of actin filaments, whereas actin-monomer-binding proteins regulate the size, localization and dynamics of the large pool of unpolymerized actin in cells. In this article, we focus on recent advances in understanding how the six evolutionarily conserved actin-monomer-binding proteins - profilin, ADF/cofilin, twinfilin, Srv2/CAP, WASP/WAVE and verprolin/WIP - interact with actin monomers and regulate their incorporation into filament ends. We also present a model of how, together, these ubiquitous actin-monomer-binding proteins contribute to cytoskeletal dynamics and actin-dependent cellular processes.

References

Feb 1, 1995·Current Opinion in Cell Biology·H Q SunH L Yin
Dec 1, 1993·European Journal of Biochemistry·M CzischT A Holak
Oct 28, 1993·Nature·C E SchuttU Lindberg
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M F CarlierD Pantaloni
Jul 3, 1997·Nature·P Lappalainen, D G Drubin
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·N RameshR S Geha
Dec 31, 1997·Biochimica Et Biophysica Acta·K SchlüterM Rothkegel
Aug 7, 1998·Molecular Biology of the Cell·P LappalainenD G Drubin
Aug 8, 1998·The Journal of Biological Chemistry·I M AntónR S Geha
Sep 17, 1998·The Journal of Biological Chemistry·L Blanchoin, T D Pollard
Jun 8, 1999·The Journal of Biological Chemistry·G VaduvaN Ramesh
Jun 15, 1999·The Journal of Cell Biology·A A RodalD C Amberg
Dec 28, 1999·Annual Review of Cell and Developmental Biology·J R Bamburg
Aug 15, 2000·Annual Review of Biophysics and Biomolecular Structure·T D PollardR D Mullins
Aug 23, 2000·The Journal of Cell Biology·A K WolvenD G Drubin
Oct 12, 2000·Proteins·G D BowmanC E Schutt
Mar 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·W WitkeD J Kwiatkowski
Apr 20, 2001·The International Journal of Biochemistry & Cell Biology·T HuffE Hannappel
May 2, 2001·Nature Cell Biology·N Martinez-QuilesN Ramesh
May 31, 2001·Science·D PantaloniM F Carlier
Nov 29, 2001·The Journal of Cell Biology·G WahlströmT I Heino
Feb 22, 2002·The Journal of Biological Chemistry·Maud HertzogMarie-France Carlier
Mar 26, 2002·FEBS Letters·Eija PaunolaPekka Lappalainen

❮ Previous
Next ❯

Citations

Feb 4, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Virpi TalmanRaimo K Tuominen
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ville O PaavilainenPekka Lappalainen
May 2, 2007·Proceedings of the National Academy of Sciences of the United States of America·J K Amisha KamalMark R Chance
Jul 11, 2006·Proceedings of the National Academy of Sciences of the United States of America·So Yeon KimW E Moerner
Jun 25, 2005·Molecular Biology of the Cell·Herwig SchülerKai Matuschewski
Jan 27, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Iain D Campbell
Nov 6, 2007·The Plant Cell·Luis VidaliMagdalena Bezanilla
Apr 3, 2009·Biology of Reproduction·Ivanna IhnatovychZuzana Strakova
Apr 29, 2009·Molecular and Cellular Biology·Hsueh-Yen KuTzu-Ching Meng
May 8, 2009·The Journal of Biological Chemistry·Keith E Bryan, Peter A Rubenstein
Oct 28, 2009·The Journal of Biological Chemistry·Shikha MalhotraK Mark Coggeshall
Jan 21, 2010·Molecular and Cellular Biology·Hiroshi TakeuchiMasato Hirata
Jun 12, 2012·Experimental & Molecular Medicine·Minjung KimJongkyung Sonn
Feb 26, 2013·The Journal of Clinical Investigation·Yong ZhouVictor J Thannickal
Nov 14, 2013·PLoS Biology·Chaohong LiuWenxia Song
Aug 21, 2013·European Biophysics Journal : EBJ·Tünde KupiJózsef Belágyi
Jan 1, 2013·Cellular and Molecular Life Sciences : CMLS·Kei Miyamoto, J B Gurdon
Oct 11, 2005·Annual Review of Cell and Developmental Biology·John CondeelisJeffrey E Segall
Nov 13, 2010·Folia Histochemica Et Cytobiologica·D GrzankaA Grzanka
Jan 6, 2010·Molecular Neurobiology·Xiao-bin Wang, Qiang Zhou
Dec 19, 2009·Cell Death and Differentiation·J E LeadshamC W Gourlay
Apr 22, 2008·FEBS Letters·Maria K Vartiainen
Jul 16, 2008·The Journal of Cell Biology·Ville O PaavilainenPekka Lappalainen
Sep 9, 2015·FEBS Letters·Lívia CzimbalekGábor Hild
Jan 19, 2005·The European Journal of Neuroscience·Henrike NeuhoffMatthias Kneussel
Oct 12, 2011·Journal of Molecular Biology·Zeynep A Oztug DurerEmil Reisler
Jan 15, 2011·Trends in Cell Biology·Jürgen SchymeinskyBarbara Walzog
Mar 15, 2016·Frontiers in Microbiology·Rahul MittalXue Z Liu
Oct 13, 2007·Journal of Theoretical Biology·Anastasios Matzavinos, Hans G Othmer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.