PMID: 8946066Jul 1, 1996Paper

Regulation of cytoskeletal functions by Rho small GTP-binding proteins in normal and cancer cells

Canadian Journal of Physiology and Pharmacology
D BoivinR Béliveau

Abstract

The actin cytoskeleton is involved in numerous cellular functions such as cell motility, mitogenesis, morphology, muscle contraction, cytokinesis, and establishment of cell polarity. The members of the Rho subfamily of small GTP-binding proteins emerge as key regulators of cytokeleton organization. Rho, Rac, and CDC42 are implicated in the regulation of actin microfilament organization of different cell structures, such as stress fibers linked to focal adhesions and membrane ruffles induced by extracellular stimuli. Rho proteins also regulate the activity of several enzymes involved in the formation of phospholipid derivatives, which could mediate their effect on the cytoskeleton. The activity of Rho proteins is regulated by many nucleotide exchange factors and GTPase-activating proteins, some of which are oncogene products, and other disease-associated proteins. The potential role of these small GTP-binding proteins in carcinogenesis is suggested by the actin reorganization seen in transforming cells and by the need for functional Rho proteins in Ras mitogenic activation.

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Citations

Nov 13, 2012·Fluids and Barriers of the CNS·Anny-Claude LuissintPierre-Olivier Couraud
Sep 25, 2001·The Laryngoscope·M T AbrahamM D Delacure
Mar 13, 2003·Molecular Biology of the Cell·Kristina KramerSharon Rounds
Jan 5, 2005·Journal of Leukocyte Biology·Joan M Cook-Mills, Tracy L Deem
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Miguel Quintela-FandinoTak W Mak
Feb 4, 2005·American Journal of Physiology. Cell Physiology·Alan S L YuEveline E Schneeberger
Dec 21, 2002·International Journal of Impotence Research·J K ParkK W Cho
Nov 15, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Craig Comiter
Jul 30, 1999·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·D BilodeauR Béliveau
May 19, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·X ZhuM A Smith

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