PMID: 8605252Feb 7, 1996Paper

Regulation of differential expression of platelet-derived growth factor alpha- and beta-receptor mRNA in normal and malignant human mesothelial cell lines

Biochimica Et Biophysica Acta
A W LangerakM A Versnel

Abstract

In earlier studies we showed that the expression of patterns of platelet-derived growth factor (PDGF) alpha- and beta-receptors differ between normal and malignant mesothelial cell lines. Normal mesothelial cells predominantly express PDGF alpha-receptor mRNA and protein, whereas most malignant mesothelioma cell lines produce PDGF beta-receptor mRNA and protein. In this paper we studied regulation of this differential PDGF receptor mRNA expression. Such an analysis is of importance in view of the suggested PDGF autocrine activity involving the PDGF beta-receptor mesothelioma cells. The results obtained in this study demonstrate that malignant mesothelioma cell lines are not only capable of PDGF beta-receptor transcription but of alpha-receptor transcription as well, as evidenced from run off analysis and RT-PCR using alpha-receptor specific primers. However, the fact that PDGF alpha-receptor mRNA could not be detected by Northern blot analysis, even after cycloheximide treatment, suggests a difference in steady-state PDGF alpha-receptor mRNA expression levels between normal and malignant mesothelial cell lines, which is likely to be caused by a post-transcriptional mechanism. In normal mesothelial cells a half-life of more than...Continue Reading

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Citations

Mar 23, 2011·Current Treatment Options in Oncology·Mamta Bagia, Anna K Nowak
Feb 1, 1997·Critical Reviews in Oncology/hematology·H C HoogstedenT van Gelder
Dec 24, 1997·Environmental Health Perspectives·J F LechnerB I Gerwin
Aug 27, 2015·Expert Review of Respiratory Medicine·Angela BononiMichele Carbone
Apr 24, 2012·Expert Opinion on Investigational Drugs·Giovanni Luca Ceresoli, Paolo Andrea Zucali
Apr 22, 2010·Expert Review of Respiratory Medicine·Carmen BelliLuciano Mutti
Oct 11, 2014·American Journal of Respiratory Cell and Molecular Biology·Nina NoskovičováKatharina Heinzelmann
Apr 21, 2009·Expert Review of Anticancer Therapy·Paolo Andrea ZucaliArmando Santoro
Jun 26, 2009·Expert Opinion on Emerging Drugs·Carmen BelliLuciano Mutti
Jul 1, 2005·Seminars in Oncology·Nicholas J VogelzangLuciano Mutti
Jun 16, 2004·Current Problems in Cancer·Harvey I PassMichele Carbone
Aug 17, 2005·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Rosa FilibertiMichela Paganuzzi
Sep 25, 2017·Journal of Internal Medicine·C-H HeldinB Westermark
Oct 3, 1999·Physiological Reviews·C H Heldin, B Westermark
Jul 3, 2007·Molecular Cancer Therapeutics·Peggy StockSatdarshan P S Monga
Feb 4, 2011·Cancer Treatment Reviews·P A ZucaliA Santoro

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