Regulation of DNA replication proteins in parasitic protozoans: possible role of CDK-like kinases

Current Genetics
Abhijit S DeshmukhSuman Kumar Dhar

Abstract

Regulatory roles of CDKs in fundamental processes including cell cycle progression and transcription are well conserved in metazoans. This family of proteins has undergone significant evolutionary divergence and specialization. Several CDK-like kinases have been identified and characterized in parasitic protozoans. However, clear functional role and physiological relevance of these proteins in protozoans still remain elusive. In continuation with the recent finding that CDK-like protein PfPK5 regulates important DNA replication protein like origin recognition complex subunit 1 in Plasmodium falciparum, here we have discussed the emerging significance of CDK1/2 homologs in DNA replication of parasitic protozoans. In fact, involvement of these proteins in crucial cellular processes projects them as potential drug targets. The possibilities that CDKs offer as potential therapeutic targets in controlling parasite progression have also been explored.

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Citations

Oct 21, 2016·Scientific Reports·Abhijit S DeshmukhMulaka Maruthi
May 19, 2017·Current Genetics·Michał Dmowski, Iwona J Fijałkowska
Mar 29, 2018·Parasites & Vectors·Holly MatthewsCatherine J Merrick
Jun 21, 2018·Memórias do Instituto Oswaldo Cruz·Kamilla Rodrigues RogerioCedric Stephan Graebin
Mar 14, 2018·G3 : Genes - Genomes - Genetics·Alex BronsteinMartin Kupiec
Apr 30, 2021·Frontiers in Cellular and Infection Microbiology·Marc-Jan GubbelsKlemens Engelberg

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