Regulation of dopamine synthesis in the rat kidney

Journal of Autonomic Pharmacology
P Soares-da-Silva, M H Fernandes

Abstract

1. Both animal and clinical studies clearly suggest a close link between dopamine production and renal delivery of sodium. 2. It appears that tubular transport of sodium and DOPA could represent the rate limiting step for the renal synthesis of dopamine; the membrane transport mechanism is sensitive to the nucleotide cyclic GMP. 3. In sodium overloaded animals AAAD activity appears to be greater than that in controls, but the tubular transport of L-DOPA might be decreased. 4. Since the final product of an increased sodium delivery to the kidney is an increased urinary excretion of dopamine, it might be hypothesized that the outward transport of newly formed dopamine in tubular epithelial cells is also affected by high tubular sodium.

References

Jan 1, 1990·Journal of Autonomic Pharmacology·P Soares-da-Silva, M H Fernandes
Mar 1, 1984·Canadian Journal of Physiology and Pharmacology·A D Baines, R Drangova
Jun 1, 1982·Kidney International·J V Bonventre, A Leaf
Jan 28, 1980·Life Sciences·A D Baines, W Chan

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Citations

Nov 3, 1992·Biochemical Pharmacology·P Soares-da-Silva
Jan 5, 1996·Biological Psychology·D Vaitl
Nov 28, 1997·Biochemical Pharmacology·P Soares-da-SilvaM P Serrão
Aug 6, 1997·European Journal of Pharmacology·P GomesP Soares-da-Silva
Dec 5, 1998·Pharmacology & Therapeutics·P A JoseR A Felder
Oct 1, 1996·Diabetes Research and Clinical Practice·O SegersG Somers
Apr 1, 1997·The International Journal of Biochemistry & Cell Biology·J T GuimarãesP Soares-da-Silva
Jan 1, 1993·Fundamental & Clinical Pharmacology·M A Vieira-Coelho, P Soares-da-Silva
Mar 1, 1991·British Journal of Pharmacology·M H FernandesP Soares-da-Silva
Apr 1, 1992·British Journal of Pharmacology·P Soares-da-Silva, M H Fernandes
Jun 1, 1993·British Journal of Pharmacology·P Soares-da-Silva
Jun 1, 1994·British Journal of Pharmacology·P Soares-da-SilvaP C Pinto-do-O
Apr 1, 1995·British Journal of Pharmacology·P Soares-da-SilvaA Albino-Teixeira
Jun 1, 1996·British Journal of Pharmacology·P C Pinto-do-O, P Soares-da-Silva
Nov 1, 1991·Acta Physiologica Scandinavica·P Soares-Da-Silva, M H Fernandes
Aug 1, 1992·Acta Physiologica Scandinavica·M H Fernandes, P Soares-da-Silva
Jul 1, 1993·Acta Physiologica Scandinavica·P Soares-da-SilvaM Pestana
May 10, 2000·Clinical and Experimental Hypertension : CHE·P Soares-da-SilvaM Cerqueira-Gomes
Aug 11, 2000·Clinical and Experimental Hypertension : CHE·V A Lucas-TeixeiraP Soares-da-Silva
Apr 25, 2001·Kidney International·M A Vieira-CoelhoP Soares-da-Silva
Sep 5, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A FerreiraP Soares-Da-Silva
Aug 11, 2004·European Journal of Heart Failure·Margarida AlvelosPatrício Soares-Da-Silva
Apr 26, 2003·Acta Physiologica Scandinavica·B Sampaio-MaiaM Pestana
Sep 1, 1992·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·P Soares-da-Silva
Nov 10, 2015·Experimental Physiology·Patrício Soares-da-SilvaFernando Magro
Oct 8, 1999·Journal of Autonomic Pharmacology·B Sampaio-MaiaP Soares-da-Silva
Jan 22, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·João S AmaralPatrício Soares-da-Silva
Aug 10, 2012·Experimental Biology and Medicine·Mónica Moreira-RodriguesManuel Pestana
Oct 16, 1999·Hypertension·M A Vieira-CoelhoM F Lokhandwala
Mar 29, 2007·American Journal of Nephrology·M Moreira-RodriguesM Pestana
Feb 24, 2005·Journal of Cardiovascular Pharmacology·Margarida AlvelosPatrício Soares-da-Silva
Jan 1, 1990·Journal of Autonomic Pharmacology·P Soares-da-Silva, M H Fernandes
Feb 1, 2007·American Journal of Physiology. Renal Physiology·Maria João PinhoPatrício Soares-da-Silva
Aug 30, 2013·American Journal of Physiology. Renal Physiology·Oleg L ZaikaOleh Pochynyuk
Nov 30, 2000·American Journal of Physiology. Renal Physiology·M A Vieira-CoelhoP Soares-da-Silva
Apr 1, 1992·British Journal of Pharmacology·P Soares-da-Silva, M H Fernandes

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