Regulation of dynorphin gene expression by kappa-opioid agonist treatment

Neuroreport
Stephanie L CollinsSari Izenwasser

Abstract

The effects of K-opioid agonist treatment on prodynorphin mRNA expression in the rat brain were studied. Rats were treated with the selective kappa-opioid agonist U-69593 or vehicle for 5 days and prodynorphin mRNA was measured on day 8 (3 days after the last injection) or 22 (17 days after the last injection). On day 8 prodynorphin mRNA was increased in the hypothalamus and decreased in the striatum, frontal cortex, and hippocampus of rats treated with U-69593. On day 22, prodynorphin mRNA was increased in the hypothalamus, frontal cortex and striatum of U-69593 treated rats. These findings suggests that kappa-opioid receptor agonist treatment has long-term, continually changing effects on prodynorphin mRNA expression.

References

Mar 1, 1992·Brain Research. Molecular Brain Research·Y L HurdC R Gerfen
Sep 1, 1993·Brain Research. Molecular Brain Research·R SpanglerM J Kreek
Feb 28, 2001·European Journal of Pharmacology·P RomualdiS Izenwasser
Aug 30, 2001·European Journal of Pharmacology·S L CollinsS Izenwasser
Sep 8, 2001·Behavioural Pharmacology·S L CollinsS Izenwasser

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Citations

Nov 13, 2003·Peptides·Richard J Bodnar, Maria M Hadjimarkou
Oct 1, 2009·Physiological Reviews·Julie Le MerrerBrigitte L Kieffer

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