Abstract
The effects of K-opioid agonist treatment on prodynorphin mRNA expression in the rat brain were studied. Rats were treated with the selective kappa-opioid agonist U-69593 or vehicle for 5 days and prodynorphin mRNA was measured on day 8 (3 days after the last injection) or 22 (17 days after the last injection). On day 8 prodynorphin mRNA was increased in the hypothalamus and decreased in the striatum, frontal cortex, and hippocampus of rats treated with U-69593. On day 22, prodynorphin mRNA was increased in the hypothalamus, frontal cortex and striatum of U-69593 treated rats. These findings suggests that kappa-opioid receptor agonist treatment has long-term, continually changing effects on prodynorphin mRNA expression.
References
Jan 1, 1992·Life Sciences·T NabeshimaT Kameyama
Mar 1, 1992·Brain Research. Molecular Brain Research·Y L HurdC R Gerfen
Nov 1, 1991·Brain Research·P RomualdiS Ferri
Jan 22, 1982·Science·C ChavkinA Goldstein
May 1, 1983·Molecular and Cellular Biology·P GunningL Kedes
Sep 1, 1993·Brain Research. Molecular Brain Research·R SpanglerM J Kreek
Aug 15, 1994·Neuroreport·E M UnterwaldM J Kreek
May 1, 1993·Neuroreport·J B DaunaisJ F McGinty
Jul 9, 1993·Brain Research·C A HeidbrederT S Shippenberg
Aug 1, 1996·Brain Research. Molecular Brain Research·P RomualdiS Ferri
Sep 2, 1996·Neuroreport·R SpanglerM J Kreek
Apr 4, 1998·Brain Research. Molecular Brain Research·A M Mathieu-Kia, M J Besson
Jul 29, 1998·Neuroscience·J TurchanR Przewłocki
Aug 3, 1999·Neuroscience·F AguadoJ Blasi
Aug 6, 1999·Psychopharmacology·S SchenkT S Shippenberg
Nov 11, 1999·Neuroscience Letters·A RosinJ Georgieva
Oct 18, 2000·Journal of Neurochemistry·D H AdamsK A Keefe
Feb 28, 2001·European Journal of Pharmacology·P RomualdiS Izenwasser
Aug 30, 2001·European Journal of Pharmacology·S L CollinsS Izenwasser
Sep 8, 2001·Behavioural Pharmacology·S L CollinsS Izenwasser
Citations
Nov 13, 2003·Peptides·Richard J Bodnar, Maria M Hadjimarkou
Oct 1, 2011·Addiction Biology·Igor BazovGeorgy Bakalkin
Feb 10, 2009·Neuropeptides·K MagnussonM Hallberg
Apr 9, 2008·European Journal of Pharmacology·Elena ZakharovaSari Izenwasser
May 15, 2007·Brain Research Bulletin·Claudio D'AddarioPatrizia Romualdi
Oct 24, 2006·Neuroscience·C D'AddarioP Romualdi
Feb 25, 2006·Synapse·J BovéC Marin
Dec 14, 2004·Experimental Neurology·C MarinE Tolosa
Oct 1, 2009·Physiological Reviews·Julie Le MerrerBrigitte L Kieffer