Regulation of early lung morphogenesis: questions, facts and controversies

Development
W V Cardoso, Jining Lü

Abstract

During early respiratory system development, the foregut endoderm gives rise to the tracheal and lung cell progenitors. Through branching morphogenesis, and in coordination with vascular development, a tree-like structure of epithelial tubules forms and differentiates to produce the airways and alveoli. Recent studies have implicated the fibroblast growth factor, sonic hedgehog, bone morphogenetic protein, retinoic acid and Wnt signaling pathways, and various transcription factors in regulating the initial stages of lung development. However, the precise roles of these molecules and how they interact in the developing lung is subject to debate. Here, we review early stages in lung development and highlight questions and controversies regarding their molecular regulation.

References

Dec 1, 1991·American Journal of Respiratory Cell and Molecular Biology·R W PeltonH L Moses
Jun 24, 1994·Science·J J LetterioA B Roberts
Aug 1, 1996·American Journal of Respiratory Cell and Molecular Biology·C W BogueH C Jacobs
Aug 1, 1996·Developmental Dynamics : an Official Publication of the American Association of Anatomists·D L ChapmanV E Papaioannou
May 1, 1997·American Journal of Respiratory Cell and Molecular Biology·D E deMelloL M Reid
Jun 15, 1997·Developmental Biology·P J MiettinenR Derynck
May 28, 1998·Mechanisms of Development·L D ZakinP Brûlet
Sep 10, 1998·Nature Genetics·Y LitingtungC Chiang
Sep 19, 1998·Developmental Biology·W Y ParkW V Cardoso
Oct 13, 1998·Current Biology : CB·C V PepicelliA P McMahon
Oct 24, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·H NogawaW V Cardoso
Dec 16, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Y IshiiS Yasugi
Jan 23, 1999·Nature Genetics·K SekineS Kato
Jan 28, 1999·American Journal of Respiratory Cell and Molecular Biology·L J MugliaJ A Majzoub
Apr 23, 1999·The Journal of Biological Chemistry·W LuW L McKeehan
Jun 26, 1999·Science·R J Metzger, M A Krasnow
Jul 20, 1999·The Journal of Biological Chemistry·M A WaniJ B Lingrel
Aug 14, 1999·Mechanisms of Development·D LebecheW V Cardoso
Sep 4, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J S ColvinD M Ornitz
Dec 28, 1999·Annual Review of Cell and Developmental Biology·J M Wells, D A Melton

❮ Previous
Next ❯

Citations

Jul 10, 2007·Pediatric Surgery International·Edwin C Jesudason
Nov 13, 2012·Pediatric Surgery International·Ana Catarina FragosoJuan A Tovar
Sep 7, 2007·Cell and Tissue Research·Darrell N Kotton, Alan Fine
Mar 18, 2009·Cell and Tissue Research·Yasuko NakamuraFumio Endo
Nov 4, 2009·Cell and Tissue Research·Kwok Yeung TsangKathryn S E Cheah
Sep 17, 2010·Functional & Integrative Genomics·Heather A AdamsSandra L Rodriguez-Zas
Apr 30, 2013·Cancer Metastasis Reviews·David Tarin
Nov 23, 2006·Journal of Mammary Gland Biology and Neoplasia·Pengfei LuZena Werb
Nov 17, 2009·In Vitro Cellular & Developmental Biology. Animal·Jinhyung ParkPeter C W Kim
Jun 6, 2008·Nature·David Warburton
Oct 29, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Anja KrauseStefan Worgall
May 9, 2008·Nature·Ross J MetzgerMark A Krasnow
Jun 10, 2008·Nature Genetics·Yuzhen ZhangEdward E Morrisey
Jan 24, 2009·Nature Reviews. Cancer·Darci T ButcherValerie M Weaver
Nov 6, 2009·Nature Reviews. Molecular Cell Biology·Markus AffolterEmmanuel Caussinus
Nov 26, 2008·Oncogene·J I LopezV M Weaver
Apr 25, 2009·Tissue Engineering. Part a·Blair RoszellChristine M Finck
Mar 13, 2010·Human Molecular Genetics·Laura L YatesCharlotte H Dean
Aug 1, 2009·Integrative and Comparative Biology·Susan J Crockford
Sep 10, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Chad M VezinaRichard E Peterson
Nov 8, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Kevin M KranslerJames R Olson
Jul 31, 2010·Science·Tomohiro OnoderaKenneth M Yamada
Jul 9, 2008·Biochemistry. Biokhimii︠a︡·N L Lazarevich, D I Fleishman
Jul 7, 2009·Annual Review of Cell and Developmental Biology·Aaron M Zorn, James M Wells
Feb 23, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·J Davin MillerLawrence S Prince
Jan 31, 2009·Circulation Research·Arie Horowitz, Michael Simons
Jun 7, 2008·American Journal of Respiratory and Critical Care Medicine·Reiko KurotaniShioko Kimura
Oct 10, 2009·American Journal of Respiratory and Critical Care Medicine·Alvin T KhoThomas J Mariani
Oct 5, 2010·American Journal of Respiratory and Critical Care Medicine·Nikolaus KneidingerMelanie Königshoff
Mar 26, 2010·American Journal of Respiratory and Critical Care Medicine·Dick Tibboel, Alan H Jobe
Jun 7, 2011·American Journal of Respiratory and Critical Care Medicine·Jeffrey A WhitsettYutaka Maeda
Jul 30, 2011·American Journal of Respiratory and Critical Care Medicine·Jamie L ToddScott M Palmer
Apr 21, 2012·American Journal of Respiratory and Critical Care Medicine·Darrell N Kotton
Sep 22, 2012·American Journal of Respiratory and Critical Care Medicine·Jason Rock, Melanie Königshoff
Feb 19, 2013·American Journal of Respiratory and Critical Care Medicine·Ewald R Weibel
Dec 5, 2006·American Journal of Respiratory Cell and Molecular Biology·Kate G AckermanDavid R Beier
Apr 19, 2008·American Journal of Respiratory Cell and Molecular Biology·Sílvia GonzagaAlan W Flake
Jul 31, 2008·American Journal of Respiratory Cell and Molecular Biology·Alvin T KhoThomas J Mariani
Nov 4, 2008·American Journal of Respiratory Cell and Molecular Biology·Joshua C SnyderBarry R Stripp
Mar 31, 2009·American Journal of Respiratory Cell and Molecular Biology·Melanie Königshoff, Oliver Eickelberg
Feb 9, 2010·American Journal of Respiratory Cell and Molecular Biology·Aliete LangsdorfXingbin Ai
Aug 11, 2012·American Journal of Respiratory Cell and Molecular Biology·Yan Li, R Ilona Linnoila

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

© 2022 Meta ULC. All rights reserved